TY - JOUR
T1 - Relationship of Medication Management Test-Revised (MMT-R) performance to neuropsychological functioning and antiretroviral adherence in adults with HIV
AU - Patton, Doyle E.
AU - Woods, Steven Paul
AU - Franklin, Donald
AU - Cattie, Jordan E.
AU - Heaton, Robert K.
AU - Collier, Ann C.
AU - Marra, Christina
AU - Clifford, David
AU - Gelman, Benjamin
AU - McArthur, Justin
AU - Morgello, Susan
AU - Simpson, Susan
AU - McCutchan, J. Allen
AU - Grant, Igor
N1 - Funding Information:
Acknowledgments This research was supported by NIH contract N01 MH2205 (CHARTER; PI: I. Grant). Participating sites include: Johns Hopkins University (J. McArthur); Mt. Sinai School of Medicine (S. Morgello & D. Simpson); University of California, San Diego (J.A. McCutchan); University of Texas Medical Branch, Galveston (B. Gelman); University of Washington, Seattle (A. C. Collier & C. Marra); Washington University, St. Louis (D. Clifford).
PY - 2012/11
Y1 - 2012/11
N2 - While performance-based tests of everyday functioning offer promise in facilitating diagnosis and classification of HIV-associated neurocognitive disorders (HAND), there remains a dearth of well-validated instruments. In the present study, clinical correlates of performance on one such measure (i.e., Medication Management Test - Revised; MMT-R) were examined in 448 HIV+ adults who were prescribed antiretroviral therapy. Significant bivariate relationships were found between MMT-R scores and demographics (e.g., education), hepatitis C coinfection, estimated premorbid IQ, neuropsychological functioning, and practical work abilities. MMT-R scores were not related to HIV disease severity, psychiatric factors, or self-reported adherence among participants with a broad range of current health status. However, lower MMT-R scores were strongly and uniquely associated with poorer adherence among participants with CD4 T cell counts <200. In multivariate analyses, MMT-R scores were predicted by practical work abilities, estimated premorbid functioning, attention/working memory, learning, and education. Findings provide overall mixed support for the construct validity of the MMT-R and are discussed in the context of their clinical and research implications for evaluation of HAND.
AB - While performance-based tests of everyday functioning offer promise in facilitating diagnosis and classification of HIV-associated neurocognitive disorders (HAND), there remains a dearth of well-validated instruments. In the present study, clinical correlates of performance on one such measure (i.e., Medication Management Test - Revised; MMT-R) were examined in 448 HIV+ adults who were prescribed antiretroviral therapy. Significant bivariate relationships were found between MMT-R scores and demographics (e.g., education), hepatitis C coinfection, estimated premorbid IQ, neuropsychological functioning, and practical work abilities. MMT-R scores were not related to HIV disease severity, psychiatric factors, or self-reported adherence among participants with a broad range of current health status. However, lower MMT-R scores were strongly and uniquely associated with poorer adherence among participants with CD4 T cell counts <200. In multivariate analyses, MMT-R scores were predicted by practical work abilities, estimated premorbid functioning, attention/working memory, learning, and education. Findings provide overall mixed support for the construct validity of the MMT-R and are discussed in the context of their clinical and research implications for evaluation of HAND.
KW - Adherence
KW - Construct validity
KW - HIV
KW - Instrumental activities of daily living
KW - Medication management
KW - Neuropsychological functioning
UR - https://www.scopus.com/pages/publications/84868588464
U2 - 10.1007/s10461-012-0237-7
DO - 10.1007/s10461-012-0237-7
M3 - Article
C2 - 22722882
AN - SCOPUS:84868588464
SN - 1090-7165
VL - 16
SP - 2286
EP - 2296
JO - AIDS and Behavior
JF - AIDS and Behavior
IS - 8
ER -