Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations

C. W. Parker; C. M. Fischman; H. J. Wedner

doi:10.1073/pnas.77.11.6870

Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations

C. W. Parker, C. M. Fischman, H. J. Wedner

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

To further elucidate the role of glutathione (GSH) in the biosynthesis of slow reacting substance (SRS), SRS generation was studied in rat basophilic leukemia cells that had been preincubated with 2-cyclohexen-1-one or diethyl maleate to decrease their intracellular GSH concentrations. At low GSH levels SRS formation was markedly inhiited. The fomation of other lipoxygenase products was much less affected, although some decrease in 5-hydroxyicosatetraneoic acid formation also occurred, apparently due in part to less rapid reduction of the 5-hydroxyperoxide.

Original language	English
Pages (from-to)	6870-6873
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	77
Issue number	11 I
DOIs	https://doi.org/10.1073/pnas.77.11.6870
State	Published - 1980

Access to Document

10.1073/pnas.77.11.6870

Cite this

@article{791ff43aa63048caa3aef50ed5854bd1,

title = "Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations",

abstract = "To further elucidate the role of glutathione (GSH) in the biosynthesis of slow reacting substance (SRS), SRS generation was studied in rat basophilic leukemia cells that had been preincubated with 2-cyclohexen-1-one or diethyl maleate to decrease their intracellular GSH concentrations. At low GSH levels SRS formation was markedly inhiited. The fomation of other lipoxygenase products was much less affected, although some decrease in 5-hydroxyicosatetraneoic acid formation also occurred, apparently due in part to less rapid reduction of the 5-hydroxyperoxide.",

author = "Parker, {C. W.} and Fischman, {C. M.} and Wedner, {H. J.}",

year = "1980",

doi = "10.1073/pnas.77.11.6870",

language = "English",

volume = "77",

pages = "6870--6873",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

number = "11 I",

}

TY - JOUR

T1 - Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations

AU - Parker, C. W.

AU - Fischman, C. M.

AU - Wedner, H. J.

PY - 1980

Y1 - 1980

N2 - To further elucidate the role of glutathione (GSH) in the biosynthesis of slow reacting substance (SRS), SRS generation was studied in rat basophilic leukemia cells that had been preincubated with 2-cyclohexen-1-one or diethyl maleate to decrease their intracellular GSH concentrations. At low GSH levels SRS formation was markedly inhiited. The fomation of other lipoxygenase products was much less affected, although some decrease in 5-hydroxyicosatetraneoic acid formation also occurred, apparently due in part to less rapid reduction of the 5-hydroxyperoxide.

AB - To further elucidate the role of glutathione (GSH) in the biosynthesis of slow reacting substance (SRS), SRS generation was studied in rat basophilic leukemia cells that had been preincubated with 2-cyclohexen-1-one or diethyl maleate to decrease their intracellular GSH concentrations. At low GSH levels SRS formation was markedly inhiited. The fomation of other lipoxygenase products was much less affected, although some decrease in 5-hydroxyicosatetraneoic acid formation also occurred, apparently due in part to less rapid reduction of the 5-hydroxyperoxide.

UR - http://www.scopus.com/inward/record.url?scp=0019196005&partnerID=8YFLogxK

U2 - 10.1073/pnas.77.11.6870

DO - 10.1073/pnas.77.11.6870

M3 - Article

C2 - 6109285

AN - SCOPUS:0019196005

SN - 0027-8424

VL - 77

SP - 6870

EP - 6873

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 11 I

ER -

Relationship of biosynthesis of slow reacting substance to intracellular glutathione concentrations

Abstract

Access to Document

Other files and links

Fingerprint

Cite this