Relationship of apparent myocardial T2 and oxygenation: Towards quantification of myocardial oxygen extraction fraction

Jie Zheng, Jinghua Wang, Faith E. Rowold, Robert J. Gropler, Pamela K. Woodard

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose: To explore the relationship of myocardial T2 and oxygenation for the quantification of myocardial oxygen extraction fraction (OEF). Materials and Methods: A proposed myocardial T2-OEF relationship was evaluated by computer simulation and in nine normal dogs in vivo. The relationship was based on a simplified two-compartment T2 model. In the dogs, dipyridamole was infused intravenously to increase blood flow and change in myocardial oxygen content. The accuracy of the measurement in myocardial OEF in vivo by magnetic resonance imaging (MRI) was determined by arterial and coronary sinus blood sampling. Results: Global myocardial T 2 increased 16.1% from rest to the peak of dipyridamole-induced vasodilation (44.6 ± 2.1 msec vs. 51.4 ± 2.1 msec, P < 0.001). Corresponding OEF measured by arterial and venous (AV) sampling decreased from 0.64 ± 0.15 at rest to 0.18 ± 0.08 during the dipyridamole vasodilation, whereas OEF calculated by MRI at the peak effect of dipyridamole was 20 ± 4%. Global myocardial OEF measured dynamically by MRI showed a strong correlation with OEF measured by blood sampling (correlation coefficient (CC) = 0.83) during pharmacologic vasodilation. Conclusion: When combined with vasodilator stress, assessment of OEF may provide a putative measure of myocardial flow reserve, allowing consecutive monitoring of myocardial dose-responses to a variety of interventions and offering a new tool for the detection of coronary artery disease.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Aug 2004


  • Cardiac MRI
  • Myocardium perfusion
  • Oxygen extraction
  • T
  • Vasodilation


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