TY - JOUR
T1 - Relationship of 5-HTTLPR genotypes and depression risk in the presence of trauma in a female twin sample
AU - Chorbov, Vesselin M.
AU - Lobos, Elizabeth A.
AU - Todorov, Alexandre A.
AU - Heath, Andrew C.
AU - Botteron, Kelly N.
AU - Todd, Richard D.
PY - 2007/9/5
Y1 - 2007/9/5
N2 - Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5-HTT) in the development of mood disorders. In the present study of a sample of 247 young adult female twins from Missouri, we examine whether this polymorphism interacts with the effect of adverse life events to increase risk for developing depression. We found a significant interaction between the number of high-activity LA alleles and exposure to trauma (OR =1.70, P < 0.0001). This differs from previous reports, in that the higher activity genotypes (LA/LA, LA/S, LA/L G), rather than the low activity genotypes (S/S, S/LG, LG/LG), are associated with an increased incidence of major depressive disease (MDD) in the presence of environmental trauma.
AB - Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5-HTT) in the development of mood disorders. In the present study of a sample of 247 young adult female twins from Missouri, we examine whether this polymorphism interacts with the effect of adverse life events to increase risk for developing depression. We found a significant interaction between the number of high-activity LA alleles and exposure to trauma (OR =1.70, P < 0.0001). This differs from previous reports, in that the higher activity genotypes (LA/LA, LA/S, LA/L G), rather than the low activity genotypes (S/S, S/LG, LG/LG), are associated with an increased incidence of major depressive disease (MDD) in the presence of environmental trauma.
KW - Depression
KW - Functional polymorphism
KW - Gene-environment interaction
KW - Serotonin transporter
KW - Trauma
UR - http://www.scopus.com/inward/record.url?scp=34548697514&partnerID=8YFLogxK
U2 - 10.1002/ajmg.b.30534
DO - 10.1002/ajmg.b.30534
M3 - Article
C2 - 17455215
AN - SCOPUS:34548697514
SN - 1552-4841
VL - 144
SP - 830
EP - 833
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
IS - 6
ER -