Relationship between quality of life indicators and cardiac status indicators in chemotherapy patients

Translated title of the contribution: Povezanost med kazalniki kakovosti življenja ter kazalniki srčnega statusa pri bolnikih, ki prejemajo kemoterapijo

Blaž Matija Geršak, Andreja Kukec, Henning Steen, Moritz Montenbruck, Maja Šoštarič, Arne Kristian Schwarz, Sebastian Esch, Sebastian Kelle, Sorin Giusca, Grigorios Korosoglou, Pia Wülfing, Susan Dent, Daniel Lenihan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Aim: With the aim of improving personalized treatment of patients on chemotherapy, the objective of the study was to assess the degree of association between selected Quality of life (QoL) indicators and both clinical and imaging cardiac status indicators when detecting deterioration in QoL of these patients. Methods: In a cohort clinical study in Hamburg, from August 2017 through October 2020, 59 cancer patients, aged 18-80 years, were evaluated before chemotherapy, and at several follow-ups, using EQ-5D and SF-36 QoL questionnaires, fast strain-encoded (fast-SENC) cardiac magnetic resonance (CMR), conventional CMR, and echocardiography, and further received a clinical and biomarker examination. Data was analyzed using survival analyses. A decline of more than 5% in each observed QoL metric value was defined as the observed event. Patient were separated into groups according to the presentation of cardiotoxicity as per its clinical definition, the establishment of the indication for cardioprotective therapy initiation, and by a worsening in the value of each observed imaging metric by more than 5% in the previous follow-up compared to the corresponding pre-chemotherapy baseline value. Results: Among clinical cardiac status indicators, the indication for cardioprotective therapy showed statistically good association with QoL scores (EQ-5D p=0.028; SF-36 physical component p=0.016; SF-36 mental component p=0.012). In terms of imaging metrics, the MyoHealth segmental myocardial strain score was the only one demonstrating consistently good QoL score association (EQ-5D p=0.005; SF-36 physical component p=0.056; SF-36 mental component p=0.002). Conclusions: Established fast-SENC CMR scores are capable of highlighting patients with reduced QoL, who require more frequent/optimal management.

Translated title of the contributionPovezanost med kazalniki kakovosti življenja ter kazalniki srčnega statusa pri bolnikih, ki prejemajo kemoterapijo
Original languageSlovenian
Pages (from-to)199-209
Number of pages11
JournalZdravstveno Varstvo
Issue number4
StatePublished - Oct 20 2021


  • Hodgkin disease
  • antineoplastic agents
  • breast neoplasms
  • cardiotoxicity
  • cine
  • echocardiography
  • lymphoma
  • magnetic resonance imaging
  • quality of life
  • ventricular function - left
  • ventricular function - right


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