@article{0df7dd0155c341349887a65acfcaf8f6,
title = "Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease",
abstract = "Introduction: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). Methods: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. Results: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. Discussion: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.",
keywords = "Cerebrospinal fluid biomarkers, Cognitive function, Dominantly inherited Alzheimer's disease, Functional status, Mutation carrier, Physical activity",
author = "{Dominantly Inherited Alzheimer Network (DIAN)} and Stephan M{\"u}ller and Oliver Preische and Sohrabi, {Hamid R.} and Susanne Gr{\"a}ber and Mathias Jucker and Ringman, {John M.} and Martins, {Ralph N.} and Eric McDade and Schofield, {Peter R.} and Bernardino Ghetti and Martin Rossor and Fox, {Nick N.} and Graff-Radford, {Neill R.} and Johannes Levin and Adrian Danek and Jonathan V{\"o}glein and Stephen Salloway and Chengjie Xiong and Tammie Benzinger and Virginia Buckles and Masters, {Colin L.} and Reisa Sperling and Bateman, {Randall J.} and Morris, {John C.} and Christoph Laske",
note = "Funding Information: Funding: Data collection and sharing for this project was supported by the Dominantly Inherited Alzheimer's Network (DIAN, U19AG032438 ); funded by the National Institute on Aging (NIA), the German Center for Neurodegenerative Diseases (DZNE), and Raul Carrea Institute for Neurological Research (FLENI); and partially supported by the Research and Development Grants for Dementia from Japan Agency for Medical Research and Development , AMED , and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI).This article has been reviewed by DIAN Study investigators for scientific content and consistency of data interpretation with previous DIAN Study publications. The authors acknowledge the altruism of the participants and their families and contributions of the DIAN research and support staff at each of the participating sites for their contributions to this study. Funding Information: Funding: Data collection and sharing for this project was supported by the Dominantly Inherited Alzheimer's Network (DIAN, U19AG032438); funded by the National Institute on Aging (NIA), the German Center for Neurodegenerative Diseases (DZNE), and Raul Carrea Institute for Neurological Research (FLENI); and partially supported by the Research and Development Grants for Dementia from Japan Agency for Medical Research and Development, AMED, and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI).This article has been reviewed by DIAN Study investigators for scientific content and consistency of data interpretation with previous DIAN Study publications. The authors acknowledge the altruism of the participants and their families and contributions of the DIAN research and support staff at each of the participating sites for their contributions to this study. Publisher Copyright: {\textcopyright} 2018 the Alzheimer's Association",
year = "2018",
month = nov,
doi = "10.1016/j.jalz.2018.06.3059",
language = "English",
volume = "14",
pages = "1427--1437",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
number = "11",
}