Relationship between Oral Health and Glaucoma Traits in the United Kingdom

Rachel H. Lee; Jae H. Kang; Janey L. Wiggs; Siegfried K. Wagner; Anthony P. Khawaja; Louis R. Pasquale; Naomi Allen; Tariq Aslam; Denize Atan; Konstantinos Balaskas; Sarah Barman; Jenny Barrett; Paul Bishop; Graeme Black; Tasanee Braithwaite; Roxana Carare; Usha Chakravarthy; Michelle Chan; Sharon Chua; Alexander Day; Parul Desai; Bal Dhillon; Andrew Dick; Alexander Doney; Cathy Egan; Sarah Ennis; Paul Foster; Marcus Fruttiger; John Gallacher; David Garway-Heath; Jane Gibson; Jeremy Guggenheim; Chris Hammond; Alison Hardcastle; Simon Harding; Ruth Hogg; Pirro Hysi; Pearse Keane; Peng Khaw; Anthony Khawaja; Gerassimos Lascaratos; Thomas Littlejohns; Andrew Lotery; Robert Luben; Phil Luthert; Tom Macgillivray; Sarah Mackie; Savita Madhusudhan; Bernadette McGuinness; Gareth McKay; Martin McKibbin; Tony Moore; James Morgan; Eoin O'Sullivan; Richard Oram; Chris Owen; Praveen Patel; Euan Paterson; Tunde Peto; Axel Petzold; Nikolas Pontikos; Jugnoo Rahi; Alicja Rudnicka; Naveed Sattar; Jay Self; Panagiotis Sergouniotis; Sobha Sivaprasad; David Steel; Irene Stratton; Nicholas Strouthidis; Cathie Sudlow; Zihan Sun; Robyn Tapp; Dhanes Thomas; Emanuele Trucco; Adnan Tufail; Ananth Viswanathan; Veronique Vitart; Mike Weedon; Katie Williams; Cathy Williams; Jayne Woodside; Max Yates; Yalin Zheng; Jihye Kim; Hugo Aschard; Marleen A.H. Lentjes; Kelsey Stuart; Kian Madjedi; Alex W. Hewitt; Alexander K. Schuster; Ananth C. Viswanathan; Andrew J. Lotery; Angela J. Cree; Calvin P. Pang; Caroline Brandl; Caroline C.W. Klaver; Caroline Hayward; Chiea Chuen Khor; Ching Yu Cheng; Christopher J. Hammond; Cornelia Van Duijn; David A. Mackey; Einer Stefansson; Eranga N. Vithana; Francesca Pasutto; Fridbert Jonansson; Gudmar Thorleifsson; Jacyline Koh; James F. Wilson; Jamie E. Craig; Joëlle E. Vergroesen; John H. Fingert; Jost B. Jonas; Kári Stefánsson; Kathryn P. Burdon; Li Jia Chen; Michael Kass; Nomdo M. Jansonius; Norbert Pfeiffer; Ozren Polašek; Paul J. Foster; Paul Mitchell; Pirro G. Hysi; Robert Wojciechowski; Sjoerd J. Driessen; Stuart W.J. Tompson; Terri L. Young; Tien Y. Wong; Tin Aung; Unnur Thorsteinsdottir; Victor A. De Vries; Wishal D. Ramdas; Ya Xing Wang

doi:10.1097/IJG.0000000000002370

Relationship between Oral Health and Glaucoma Traits in the United Kingdom

Rachel H. Lee, Jae H. Kang, Janey L. Wiggs, Siegfried K. Wagner, Anthony P. Khawaja, Louis R. Pasquale, Naomi Allen, Tariq Aslam, Denize Atan, Konstantinos Balaskas, Sarah Barman, Jenny Barrett, Paul Bishop, Graeme Black, Tasanee Braithwaite, Roxana Carare, Usha Chakravarthy, Michelle Chan, Sharon Chua, Alexander DayParul Desai, Bal Dhillon, Andrew Dick, Alexander Doney, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John Gallacher, David Garway-Heath, Jane Gibson, Jeremy Guggenheim, Chris Hammond, Alison Hardcastle, Simon Harding, Ruth Hogg, Pirro Hysi, Pearse Keane, Peng Khaw, Anthony Khawaja, Gerassimos Lascaratos, Thomas Littlejohns, Andrew Lotery, Robert Luben, Phil Luthert, Tom Macgillivray, Sarah Mackie, Savita Madhusudhan, Bernadette McGuinness, Gareth McKay, Martin McKibbin, Tony Moore, James Morgan, Eoin O'Sullivan, Richard Oram, Chris Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Nikolas Pontikos, Jugnoo Rahi, Alicja Rudnicka, Naveed Sattar, Jay Self, Panagiotis Sergouniotis, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Zihan Sun, Robyn Tapp, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Ananth Viswanathan, Veronique Vitart, Mike Weedon, Katie Williams, Cathy Williams, Jayne Woodside, Max Yates, Yalin Zheng, Jihye Kim, Hugo Aschard, Marleen A.H. Lentjes, Kelsey Stuart, Kian Madjedi, Alex W. Hewitt, Alexander K. Schuster, Ananth C. Viswanathan, Andrew J. Lotery, Angela J. Cree, Calvin P. Pang, Caroline Brandl, Caroline C.W. Klaver, Caroline Hayward, Chiea Chuen Khor, Ching Yu Cheng, Christopher J. Hammond, Cornelia Van Duijn, David A. Mackey, Einer Stefansson, Eranga N. Vithana, Francesca Pasutto, Fridbert Jonansson, Gudmar Thorleifsson, Jacyline Koh, James F. Wilson, Jamie E. Craig, Joëlle E. Vergroesen, John H. Fingert, Jost B. Jonas, Kári Stefánsson, Kathryn P. Burdon, Li Jia Chen, Michael Kass, Nomdo M. Jansonius, Norbert Pfeiffer, Ozren Polašek, Paul J. Foster, Paul Mitchell, Pirro G. Hysi, Robert Wojciechowski, Sjoerd J. Driessen, Stuart W.J. Tompson, Terri L. Young, Tien Y. Wong, Tin Aung, Unnur Thorsteinsdottir, Victor A. De Vries, Wishal D. Ramdas, Ya Xing Wang

Research output: Contribution to journal › Article › peer-review

Abstract

Précis: In this cross-sectional analysis of UK Biobank participants, we find no adverse association between self-reported oral health conditions and either glaucoma or elevated intraocular pressures. Purpose: Poor oral health may cause inflammation, which accelerates the progression of neurodegenerative diseases. We investigated the relationship between oral health and glaucoma. Patients: United Kingdom Biobank participants. Methods: This is a cross-sectional analysis of participants categorized by self-reported oral health status. Multivariable linear and logistic regression models were used. Primary analysis examined the association with glaucoma prevalence. Secondary analyses examined associations with IOP, macular retinal nerve fiber layer (mRNFL), and ganglion cell inner plexiform layer (mGCIPL) thicknesses, and interaction terms with multitrait glaucoma polygenic risk scores (MTAG PRS) or intraocular pressure (IOP) PRS. Results: A total of 170,815 participants (34.3%) reported current oral health problems, including painful or bleeding gums, toothache, loose teeth, and/or denture wear. A In all, 33,059, 33,004, 14,652, and 14,613 participants were available for analysis of glaucoma, IOP, mRNFL, and mGCIPL, respectively. No association between oral health and glaucoma was identified [odds ratio (OR): 1.04, 95% CI: 0.95-1.14]. IOPs were slightly lower among those with oral disease (-0.08 mm Hg, 95% CI: -0.15, -0.009); specifically, among those with loose teeth (P=0.03) and denture-wearers (P<0.0001). mRNFL measurements were lower among those with oral health conditions (-0.14 μm, 95% CI: -0.27, -0.0009), but mGCIPL measurements (P=0.96) were not significantly different. A PRS for IOP or glaucoma did not modify relations between oral health and IOP or glaucoma (P for interactions ≥ 0.17). Conclusions: Self-reported oral health was not associated with elevated IOP or an increased risk of glaucoma. Future studies should confirm the null association between clinically diagnosed oral health conditions and glaucoma.

Original language	English
Pages (from-to)	400-408
Number of pages	9
Journal	Journal of Glaucoma
Volume	33
Issue number	6
DOIs	https://doi.org/10.1097/IJG.0000000000002370
State	Published - Jun 1 2024

Keywords

dental health
glaucoma
intraocular pressure
oral health

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10.1097/IJG.0000000000002370

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Lee, R. H., Kang, J. H., Wiggs, J. L., Wagner, S. K., Khawaja, A. P., Pasquale, L. R., Allen, N., Aslam, T., Atan, D., Balaskas, K., Barman, S., Barrett, J., Bishop, P., Black, G., Braithwaite, T., Carare, R., Chakravarthy, U., Chan, M., Chua, S., ... Wang, Y. X. (2024). Relationship between Oral Health and Glaucoma Traits in the United Kingdom. Journal of Glaucoma, 33(6), 400-408. https://doi.org/10.1097/IJG.0000000000002370

@article{52f5494968b74db89a0c2058f436911f,

title = "Relationship between Oral Health and Glaucoma Traits in the United Kingdom",

abstract = "Pr{\'e}cis: In this cross-sectional analysis of UK Biobank participants, we find no adverse association between self-reported oral health conditions and either glaucoma or elevated intraocular pressures. Purpose: Poor oral health may cause inflammation, which accelerates the progression of neurodegenerative diseases. We investigated the relationship between oral health and glaucoma. Patients: United Kingdom Biobank participants. Methods: This is a cross-sectional analysis of participants categorized by self-reported oral health status. Multivariable linear and logistic regression models were used. Primary analysis examined the association with glaucoma prevalence. Secondary analyses examined associations with IOP, macular retinal nerve fiber layer (mRNFL), and ganglion cell inner plexiform layer (mGCIPL) thicknesses, and interaction terms with multitrait glaucoma polygenic risk scores (MTAG PRS) or intraocular pressure (IOP) PRS. Results: A total of 170,815 participants (34.3%) reported current oral health problems, including painful or bleeding gums, toothache, loose teeth, and/or denture wear. A In all, 33,059, 33,004, 14,652, and 14,613 participants were available for analysis of glaucoma, IOP, mRNFL, and mGCIPL, respectively. No association between oral health and glaucoma was identified [odds ratio (OR): 1.04, 95% CI: 0.95-1.14]. IOPs were slightly lower among those with oral disease (-0.08 mm Hg, 95% CI: -0.15, -0.009); specifically, among those with loose teeth (P=0.03) and denture-wearers (P<0.0001). mRNFL measurements were lower among those with oral health conditions (-0.14 μm, 95% CI: -0.27, -0.0009), but mGCIPL measurements (P=0.96) were not significantly different. A PRS for IOP or glaucoma did not modify relations between oral health and IOP or glaucoma (P for interactions ≥ 0.17). Conclusions: Self-reported oral health was not associated with elevated IOP or an increased risk of glaucoma. Future studies should confirm the null association between clinically diagnosed oral health conditions and glaucoma.",

keywords = "dental health, glaucoma, intraocular pressure, oral health",

author = "Lee, {Rachel H.} and Kang, {Jae H.} and Wiggs, {Janey L.} and Wagner, {Siegfried K.} and Khawaja, {Anthony P.} and Pasquale, {Louis R.} and Naomi Allen and Tariq Aslam and Denize Atan and Konstantinos Balaskas and Sarah Barman and Jenny Barrett and Paul Bishop and Graeme Black and Tasanee Braithwaite and Roxana Carare and Usha Chakravarthy and Michelle Chan and Sharon Chua and Alexander Day and Parul Desai and Bal Dhillon and Andrew Dick and Alexander Doney and Cathy Egan and Sarah Ennis and Paul Foster and Marcus Fruttiger and John Gallacher and David Garway-Heath and Jane Gibson and Jeremy Guggenheim and Chris Hammond and Alison Hardcastle and Simon Harding and Ruth Hogg and Pirro Hysi and Pearse Keane and Peng Khaw and Anthony Khawaja and Gerassimos Lascaratos and Thomas Littlejohns and Andrew Lotery and Robert Luben and Phil Luthert and Tom Macgillivray and Sarah Mackie and Savita Madhusudhan and Bernadette McGuinness and Gareth McKay and Martin McKibbin and Tony Moore and James Morgan and Eoin O'Sullivan and Richard Oram and Chris Owen and Praveen Patel and Euan Paterson and Tunde Peto and Axel Petzold and Nikolas Pontikos and Jugnoo Rahi and Alicja Rudnicka and Naveed Sattar and Jay Self and Panagiotis Sergouniotis and Sobha Sivaprasad and David Steel and Irene Stratton and Nicholas Strouthidis and Cathie Sudlow and Zihan Sun and Robyn Tapp and Dhanes Thomas and Emanuele Trucco and Adnan Tufail and Ananth Viswanathan and Veronique Vitart and Mike Weedon and Katie Williams and Cathy Williams and Jayne Woodside and Max Yates and Yalin Zheng and Jihye Kim and Hugo Aschard and Lentjes, {Marleen A.H.} and Kelsey Stuart and Kian Madjedi and Hewitt, {Alex W.} and Schuster, {Alexander K.} and Viswanathan, {Ananth C.} and Lotery, {Andrew J.} and Cree, {Angela J.} and Pang, {Calvin P.} and Caroline Brandl and Klaver, {Caroline C.W.} and Caroline Hayward and Khor, {Chiea Chuen} and Cheng, {Ching Yu} and Hammond, {Christopher J.} and {Van Duijn}, Cornelia and Mackey, {David A.} and Einer Stefansson and Vithana, {Eranga N.} and Francesca Pasutto and Fridbert Jonansson and Gudmar Thorleifsson and Jacyline Koh and Wilson, {James F.} and Craig, {Jamie E.} and Vergroesen, {Jo{\"e}lle E.} and Fingert, {John H.} and Jonas, {Jost B.} and K{\'a}ri Stef{\'a}nsson and Burdon, {Kathryn P.} and Chen, {Li Jia} and Michael Kass and Jansonius, {Nomdo M.} and Norbert Pfeiffer and Ozren Pola{\v s}ek and Foster, {Paul J.} and Paul Mitchell and Hysi, {Pirro G.} and Robert Wojciechowski and Driessen, {Sjoerd J.} and Tompson, {Stuart W.J.} and Young, {Terri L.} and Wong, {Tien Y.} and Tin Aung and Unnur Thorsteinsdottir and {De Vries}, {Victor A.} and Ramdas, {Wishal D.} and Wang, {Ya Xing}",

year = "2024",

month = jun,

day = "1",

doi = "10.1097/IJG.0000000000002370",

language = "English",

volume = "33",

pages = "400--408",

journal = "Journal of Glaucoma",

issn = "1057-0829",

number = "6",

}

Lee, RH, Kang, JH, Wiggs, JL, Wagner, SK, Khawaja, AP, Pasquale, LR, Allen, N, Aslam, T, Atan, D, Balaskas, K, Barman, S, Barrett, J, Bishop, P, Black, G, Braithwaite, T, Carare, R, Chakravarthy, U, Chan, M, Chua, S, Day, A, Desai, P, Dhillon, B, Dick, A, Doney, A, Egan, C, Ennis, S, Foster, P, Fruttiger, M, Gallacher, J, Garway-Heath, D, Gibson, J, Guggenheim, J, Hammond, C, Hardcastle, A, Harding, S, Hogg, R, Hysi, P, Keane, P, Khaw, P, Khawaja, A, Lascaratos, G, Littlejohns, T, Lotery, A, Luben, R, Luthert, P, Macgillivray, T, Mackie, S, Madhusudhan, S, McGuinness, B, McKay, G, McKibbin, M, Moore, T, Morgan, J, O'Sullivan, E, Oram, R, Owen, C, Patel, P, Paterson, E, Peto, T, Petzold, A, Pontikos, N, Rahi, J, Rudnicka, A, Sattar, N, Self, J, Sergouniotis, P, Sivaprasad, S, Steel, D, Stratton, I, Strouthidis, N, Sudlow, C, Sun, Z, Tapp, R, Thomas, D, Trucco, E, Tufail, A, Viswanathan, A, Vitart, V, Weedon, M, Williams, K, Williams, C, Woodside, J, Yates, M, Zheng, Y, Kim, J, Aschard, H, Lentjes, MAH, Stuart, K, Madjedi, K, Hewitt, AW, Schuster, AK, Viswanathan, AC, Lotery, AJ, Cree, AJ, Pang, CP, Brandl, C, Klaver, CCW, Hayward, C, Khor, CC, Cheng, CY, Hammond, CJ, Van Duijn, C, Mackey, DA, Stefansson, E, Vithana, EN, Pasutto, F, Jonansson, F, Thorleifsson, G, Koh, J, Wilson, JF, Craig, JE, Vergroesen, JE, Fingert, JH, Jonas, JB, Stefánsson, K, Burdon, KP, Chen, LJ, Kass, M, Jansonius, NM, Pfeiffer, N, Polašek, O, Foster, PJ, Mitchell, P, Hysi, PG, Wojciechowski, R, Driessen, SJ, Tompson, SWJ, Young, TL, Wong, TY, Aung, T, Thorsteinsdottir, U, De Vries, VA, Ramdas, WD & Wang, YX 2024, 'Relationship between Oral Health and Glaucoma Traits in the United Kingdom', Journal of Glaucoma, vol. 33, no. 6, pp. 400-408. https://doi.org/10.1097/IJG.0000000000002370

TY - JOUR

T1 - Relationship between Oral Health and Glaucoma Traits in the United Kingdom

AU - Lee, Rachel H.

AU - Kang, Jae H.

AU - Wiggs, Janey L.

AU - Wagner, Siegfried K.

AU - Khawaja, Anthony P.

AU - Pasquale, Louis R.

AU - Allen, Naomi

AU - Aslam, Tariq

AU - Atan, Denize

AU - Balaskas, Konstantinos

AU - Barman, Sarah

AU - Barrett, Jenny

AU - Bishop, Paul

AU - Black, Graeme

AU - Braithwaite, Tasanee

AU - Carare, Roxana

AU - Chakravarthy, Usha

AU - Chan, Michelle

AU - Chua, Sharon

AU - Day, Alexander

AU - Desai, Parul

AU - Dhillon, Bal

AU - Dick, Andrew

AU - Doney, Alexander

AU - Egan, Cathy

AU - Ennis, Sarah

AU - Foster, Paul

AU - Fruttiger, Marcus

AU - Gallacher, John

AU - Garway-Heath, David

AU - Gibson, Jane

AU - Guggenheim, Jeremy

AU - Hammond, Chris

AU - Hardcastle, Alison

AU - Harding, Simon

AU - Hogg, Ruth

AU - Hysi, Pirro

AU - Keane, Pearse

AU - Khaw, Peng

AU - Khawaja, Anthony

AU - Lascaratos, Gerassimos

AU - Littlejohns, Thomas

AU - Lotery, Andrew

AU - Luben, Robert

AU - Luthert, Phil

AU - Macgillivray, Tom

AU - Mackie, Sarah

AU - Madhusudhan, Savita

AU - McGuinness, Bernadette

AU - McKay, Gareth

AU - McKibbin, Martin

AU - Moore, Tony

AU - Morgan, James

AU - O'Sullivan, Eoin

AU - Oram, Richard

AU - Owen, Chris

AU - Patel, Praveen

AU - Paterson, Euan

AU - Peto, Tunde

AU - Petzold, Axel

AU - Pontikos, Nikolas

AU - Rahi, Jugnoo

AU - Rudnicka, Alicja

AU - Sattar, Naveed

AU - Self, Jay

AU - Sergouniotis, Panagiotis

AU - Sivaprasad, Sobha

AU - Steel, David

AU - Stratton, Irene

AU - Strouthidis, Nicholas

AU - Sudlow, Cathie

AU - Sun, Zihan

AU - Tapp, Robyn

AU - Thomas, Dhanes

AU - Trucco, Emanuele

AU - Tufail, Adnan

AU - Viswanathan, Ananth

AU - Vitart, Veronique

AU - Weedon, Mike

AU - Williams, Katie

AU - Williams, Cathy

AU - Woodside, Jayne

AU - Yates, Max

AU - Zheng, Yalin

AU - Kim, Jihye

AU - Aschard, Hugo

AU - Lentjes, Marleen A.H.

AU - Stuart, Kelsey

AU - Madjedi, Kian

AU - Hewitt, Alex W.

AU - Schuster, Alexander K.

AU - Viswanathan, Ananth C.

AU - Lotery, Andrew J.

AU - Cree, Angela J.

AU - Pang, Calvin P.

AU - Brandl, Caroline

AU - Klaver, Caroline C.W.

AU - Hayward, Caroline

AU - Khor, Chiea Chuen

AU - Cheng, Ching Yu

AU - Hammond, Christopher J.

AU - Van Duijn, Cornelia

AU - Mackey, David A.

AU - Stefansson, Einer

AU - Vithana, Eranga N.

AU - Pasutto, Francesca

AU - Jonansson, Fridbert

AU - Thorleifsson, Gudmar

AU - Koh, Jacyline

AU - Wilson, James F.

AU - Craig, Jamie E.

AU - Vergroesen, Joëlle E.

AU - Fingert, John H.

AU - Jonas, Jost B.

AU - Stefánsson, Kári

AU - Burdon, Kathryn P.

AU - Chen, Li Jia

AU - Kass, Michael

AU - Jansonius, Nomdo M.

AU - Pfeiffer, Norbert

AU - Polašek, Ozren

AU - Foster, Paul J.

AU - Mitchell, Paul

AU - Hysi, Pirro G.

AU - Wojciechowski, Robert

AU - Driessen, Sjoerd J.

AU - Tompson, Stuart W.J.

AU - Young, Terri L.

AU - Wong, Tien Y.

AU - Aung, Tin

AU - Thorsteinsdottir, Unnur

AU - De Vries, Victor A.

AU - Ramdas, Wishal D.

AU - Wang, Ya Xing

PY - 2024/6/1

Y1 - 2024/6/1

N2 - Précis: In this cross-sectional analysis of UK Biobank participants, we find no adverse association between self-reported oral health conditions and either glaucoma or elevated intraocular pressures. Purpose: Poor oral health may cause inflammation, which accelerates the progression of neurodegenerative diseases. We investigated the relationship between oral health and glaucoma. Patients: United Kingdom Biobank participants. Methods: This is a cross-sectional analysis of participants categorized by self-reported oral health status. Multivariable linear and logistic regression models were used. Primary analysis examined the association with glaucoma prevalence. Secondary analyses examined associations with IOP, macular retinal nerve fiber layer (mRNFL), and ganglion cell inner plexiform layer (mGCIPL) thicknesses, and interaction terms with multitrait glaucoma polygenic risk scores (MTAG PRS) or intraocular pressure (IOP) PRS. Results: A total of 170,815 participants (34.3%) reported current oral health problems, including painful or bleeding gums, toothache, loose teeth, and/or denture wear. A In all, 33,059, 33,004, 14,652, and 14,613 participants were available for analysis of glaucoma, IOP, mRNFL, and mGCIPL, respectively. No association between oral health and glaucoma was identified [odds ratio (OR): 1.04, 95% CI: 0.95-1.14]. IOPs were slightly lower among those with oral disease (-0.08 mm Hg, 95% CI: -0.15, -0.009); specifically, among those with loose teeth (P=0.03) and denture-wearers (P<0.0001). mRNFL measurements were lower among those with oral health conditions (-0.14 μm, 95% CI: -0.27, -0.0009), but mGCIPL measurements (P=0.96) were not significantly different. A PRS for IOP or glaucoma did not modify relations between oral health and IOP or glaucoma (P for interactions ≥ 0.17). Conclusions: Self-reported oral health was not associated with elevated IOP or an increased risk of glaucoma. Future studies should confirm the null association between clinically diagnosed oral health conditions and glaucoma.

AB - Précis: In this cross-sectional analysis of UK Biobank participants, we find no adverse association between self-reported oral health conditions and either glaucoma or elevated intraocular pressures. Purpose: Poor oral health may cause inflammation, which accelerates the progression of neurodegenerative diseases. We investigated the relationship between oral health and glaucoma. Patients: United Kingdom Biobank participants. Methods: This is a cross-sectional analysis of participants categorized by self-reported oral health status. Multivariable linear and logistic regression models were used. Primary analysis examined the association with glaucoma prevalence. Secondary analyses examined associations with IOP, macular retinal nerve fiber layer (mRNFL), and ganglion cell inner plexiform layer (mGCIPL) thicknesses, and interaction terms with multitrait glaucoma polygenic risk scores (MTAG PRS) or intraocular pressure (IOP) PRS. Results: A total of 170,815 participants (34.3%) reported current oral health problems, including painful or bleeding gums, toothache, loose teeth, and/or denture wear. A In all, 33,059, 33,004, 14,652, and 14,613 participants were available for analysis of glaucoma, IOP, mRNFL, and mGCIPL, respectively. No association between oral health and glaucoma was identified [odds ratio (OR): 1.04, 95% CI: 0.95-1.14]. IOPs were slightly lower among those with oral disease (-0.08 mm Hg, 95% CI: -0.15, -0.009); specifically, among those with loose teeth (P=0.03) and denture-wearers (P<0.0001). mRNFL measurements were lower among those with oral health conditions (-0.14 μm, 95% CI: -0.27, -0.0009), but mGCIPL measurements (P=0.96) were not significantly different. A PRS for IOP or glaucoma did not modify relations between oral health and IOP or glaucoma (P for interactions ≥ 0.17). Conclusions: Self-reported oral health was not associated with elevated IOP or an increased risk of glaucoma. Future studies should confirm the null association between clinically diagnosed oral health conditions and glaucoma.

KW - dental health

KW - glaucoma

KW - intraocular pressure

KW - oral health

UR - http://www.scopus.com/inward/record.url?scp=85195227784&partnerID=8YFLogxK

U2 - 10.1097/IJG.0000000000002370

DO - 10.1097/IJG.0000000000002370

M3 - Article

C2 - 38506820

AN - SCOPUS:85195227784

SN - 1057-0829

VL - 33

SP - 400

EP - 408

JO - Journal of Glaucoma

JF - Journal of Glaucoma

IS - 6

ER -

Relationship between Oral Health and Glaucoma Traits in the United Kingdom

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