TY - JOUR
T1 - Relationship between angiographic vasospasm and regional hypoperfusion in aneurysmal subarachnoid hemorrhage
AU - Dhar, Rajat
AU - Scalfani, Michael T.
AU - Blackburn, Spiros
AU - Zazulia, Allyson R.
AU - Videen, Tom
AU - Diringer, Michael
PY - 2012/7
Y1 - 2012/7
N2 - Background and Purpose-Angiographic vasospasm frequently complicates subarachnoid hemorrhage and has been implicated in the development of delayed cerebral ischemia. Whether large-vessel narrowing adequately accounts for the critical reductions in regional cerebral blood flow underlying ischemia is unclear. We sought to clarify the relationship between angiographic vasospasm and regional hypoperfusion. Methods-Twenty-five patients with aneurysmal subarachnoid hemorrhage underwent cerebral catheter angiography and O-positron emission tomographic imaging within 1 day of each other (median of 7 days after subarachnoid hemorrhage). Severity of vasospasm was assessed in each intracranial artery, whereas cerebral blood flow and oxygen extraction fraction were measured in 28 brain regions distributed across these vascular territories. We analyzed the association between vasospasm and perfusion and compared frequency of hypoperfusion (cerebral blood flow <25 mL/100 g/min) and oligemia (low oxygen delivery with oxygen extraction fraction ≥0.5) in territories with versus without significant vasospasm. Results-Twenty-four percent of 652 brain regions were supplied by vessels with significant vasospasm. Cerebral blood flow was lower in such regions (38.6±12 versus 48.7±16 mL/100 g/min), whereas oxygen extraction fraction was higher (0.48±0.19 versus 0.37±0.14, both P<0.001). Hypoperfusion was seen in 46 regions (7%), but 66% of these were supplied by vessels with no significant vasospasm; 24% occurred in patients without angiographic vasospasm. Similarly, oligemia occurred more frequently outside territories with vasospasm. Conclusions-Angiographic vasospasm is associated with reductions in cerebral perfusion. However, regional hypoperfusion and oligemia frequently occurred in territories and patients without vasospasm. Other factors in addition to large-vessel narrowing must contribute to critical reductions in perfusion.
AB - Background and Purpose-Angiographic vasospasm frequently complicates subarachnoid hemorrhage and has been implicated in the development of delayed cerebral ischemia. Whether large-vessel narrowing adequately accounts for the critical reductions in regional cerebral blood flow underlying ischemia is unclear. We sought to clarify the relationship between angiographic vasospasm and regional hypoperfusion. Methods-Twenty-five patients with aneurysmal subarachnoid hemorrhage underwent cerebral catheter angiography and O-positron emission tomographic imaging within 1 day of each other (median of 7 days after subarachnoid hemorrhage). Severity of vasospasm was assessed in each intracranial artery, whereas cerebral blood flow and oxygen extraction fraction were measured in 28 brain regions distributed across these vascular territories. We analyzed the association between vasospasm and perfusion and compared frequency of hypoperfusion (cerebral blood flow <25 mL/100 g/min) and oligemia (low oxygen delivery with oxygen extraction fraction ≥0.5) in territories with versus without significant vasospasm. Results-Twenty-four percent of 652 brain regions were supplied by vessels with significant vasospasm. Cerebral blood flow was lower in such regions (38.6±12 versus 48.7±16 mL/100 g/min), whereas oxygen extraction fraction was higher (0.48±0.19 versus 0.37±0.14, both P<0.001). Hypoperfusion was seen in 46 regions (7%), but 66% of these were supplied by vessels with no significant vasospasm; 24% occurred in patients without angiographic vasospasm. Similarly, oligemia occurred more frequently outside territories with vasospasm. Conclusions-Angiographic vasospasm is associated with reductions in cerebral perfusion. However, regional hypoperfusion and oligemia frequently occurred in territories and patients without vasospasm. Other factors in addition to large-vessel narrowing must contribute to critical reductions in perfusion.
KW - brain ischemia
KW - subarachnoid hemorrhage
KW - vasospasm
UR - http://www.scopus.com/inward/record.url?scp=84863328207&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.111.646836
DO - 10.1161/STROKEAHA.111.646836
M3 - Article
C2 - 22492520
AN - SCOPUS:84863328207
SN - 0039-2499
VL - 43
SP - 1788
EP - 1794
JO - Stroke
JF - Stroke
IS - 7
ER -