Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy

Constantin T. Yiannoutsos; Eugene O. Major; Blanche Curfman; Peter N. Jensen; Maneth Gravell; Jean Hou; David B. Clifford; Colin D. Hall

doi:10.1002/1531-8249(199906)45:6<816::AID-ANA21>3.0.CO;2-W

Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy

Constantin T. Yiannoutsos
, Eugene O. Major
, Blanche Curfman
, Peter N. Jensen
, Maneth Gravell
, Jean Hou
, David B. Clifford
, Colin D. Hall

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

The detection and semiquantitation of JC virus (JCV) DNA in cerebrospinal fluid (CSF) is prognostic of survival and is a marker of the course of progressive multifocal leukoencephalopathy (PML). CSF samples from 15 acquired immunodeficiency syndrome (AIDS) patients with biopsy-proven PML were analyzed by semiquantitative polymerase chain reaction (PCR). A low JCV burden was predictive of longer survival compared with a high JCV burden (median survival from entry, 24 [2-63] vs 7.6 [4-17] weeks). Further analyses indicated a possible threshold of 50 to 100 copies/μl separating high- and moderate-risk cases. Patients with a JCV load below this level survived longer than those with a JCV load above it.

Original language	English
Pages (from-to)	816-820
Number of pages	5
Journal	Annals of neurology
Volume	45
Issue number	6
DOIs	https://doi.org/10.1002/1531-8249(199906)45:6<816::AID-ANA21>3.0.CO;2-W
State	Published - 1999

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10.1002/1531-8249(199906)45:6<816::AID-ANA21>3.0.CO;2-W

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Yiannoutsos, C. T., Major, E. O., Curfman, B., Jensen, P. N., Gravell, M., Hou, J., Clifford, D. B., & Hall, C. D. (1999). Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy. Annals of neurology, 45(6), 816-820. https://doi.org/10.1002/1531-8249(199906)45:6<816::AID-ANA21>3.0.CO;2-W

@article{7060fef548394067a15eae327279f053,

title = "Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy",

abstract = "The detection and semiquantitation of JC virus (JCV) DNA in cerebrospinal fluid (CSF) is prognostic of survival and is a marker of the course of progressive multifocal leukoencephalopathy (PML). CSF samples from 15 acquired immunodeficiency syndrome (AIDS) patients with biopsy-proven PML were analyzed by semiquantitative polymerase chain reaction (PCR). A low JCV burden was predictive of longer survival compared with a high JCV burden (median survival from entry, 24 [2-63] vs 7.6 [4-17] weeks). Further analyses indicated a possible threshold of 50 to 100 copies/μl separating high- and moderate-risk cases. Patients with a JCV load below this level survived longer than those with a JCV load above it.",

author = "Yiannoutsos, \{Constantin T.\} and Major, \{Eugene O.\} and Blanche Curfman and Jensen, \{Peter N.\} and Maneth Gravell and Jean Hou and Clifford, \{David B.\} and Hall, \{Colin D.\}",

year = "1999",

doi = "10.1002/1531-8249(199906)45:6<816::AID-ANA21>3.0.CO;2-W",

language = "English",

volume = "45",

pages = "816--820",

journal = "Annals of neurology",

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Yiannoutsos, CT, Major, EO, Curfman, B, Jensen, PN, Gravell, M, Hou, J, Clifford, DB & Hall, CD 1999, 'Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy', Annals of neurology, vol. 45, no. 6, pp. 816-820. https://doi.org/10.1002/1531-8249(199906)45:6<816::AID-ANA21>3.0.CO;2-W

Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy. / Yiannoutsos, Constantin T.; Major, Eugene O.; Curfman, Blanche et al.
In: Annals of neurology, Vol. 45, No. 6, 1999, p. 816-820.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy

AU - Yiannoutsos, Constantin T.

AU - Major, Eugene O.

AU - Curfman, Blanche

AU - Jensen, Peter N.

AU - Gravell, Maneth

AU - Hou, Jean

AU - Clifford, David B.

AU - Hall, Colin D.

PY - 1999

Y1 - 1999

N2 - The detection and semiquantitation of JC virus (JCV) DNA in cerebrospinal fluid (CSF) is prognostic of survival and is a marker of the course of progressive multifocal leukoencephalopathy (PML). CSF samples from 15 acquired immunodeficiency syndrome (AIDS) patients with biopsy-proven PML were analyzed by semiquantitative polymerase chain reaction (PCR). A low JCV burden was predictive of longer survival compared with a high JCV burden (median survival from entry, 24 [2-63] vs 7.6 [4-17] weeks). Further analyses indicated a possible threshold of 50 to 100 copies/μl separating high- and moderate-risk cases. Patients with a JCV load below this level survived longer than those with a JCV load above it.

AB - The detection and semiquantitation of JC virus (JCV) DNA in cerebrospinal fluid (CSF) is prognostic of survival and is a marker of the course of progressive multifocal leukoencephalopathy (PML). CSF samples from 15 acquired immunodeficiency syndrome (AIDS) patients with biopsy-proven PML were analyzed by semiquantitative polymerase chain reaction (PCR). A low JCV burden was predictive of longer survival compared with a high JCV burden (median survival from entry, 24 [2-63] vs 7.6 [4-17] weeks). Further analyses indicated a possible threshold of 50 to 100 copies/μl separating high- and moderate-risk cases. Patients with a JCV load below this level survived longer than those with a JCV load above it.

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M3 - Article

C2 - 10360779

AN - SCOPUS:0032976203

SN - 0364-5134

VL - 45

SP - 816

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JO - Annals of neurology

JF - Annals of neurology

IS - 6

ER -

Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy

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