Abstract

Intrinsically disordered proteins (IDPs) showcase the importance of conformational plasticity and heterogeneity in protein function. We summarize recent advances that connect information encoded in IDP sequences to their conformational properties and functions. We focus on insights obtained through a combination of atomistic simulations and biophysical measurements that are synthesized into a coherent framework using polymer physics theories.

Original languageEnglish
Pages (from-to)102-112
Number of pages11
JournalCurrent Opinion in Structural Biology
Volume32
DOIs
StatePublished - Jun 1 2015

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