TY - JOUR
T1 - Rehabilitation after stroke
T2 - Current state of the science
AU - Carter, Alex R.
AU - Connor, Lisa T.
AU - Dromerick, Alexander W.
PY - 2010/5
Y1 - 2010/5
N2 - Stroke rehabilitation is evolving into a clinical field based on the neuroscience of recovery and restoration. There has been substantial growth in the number and quality of clinical trials performed. Much effort now is directed toward motor restoration and is being led by trials of constraint-induced movement therapy. Although the results do not necessarily support that constraint-induced movement therapy is superior to other training methods, this treatment has become an important vehicle for developing clinical trial methods and studying the physiology underlying activity-based rehabilitation strategies. Other promising interventions include robotic therapy delivery, magnetic and electrical cortical stimulation, visualization, and constraint-driven aphasia therapies. Amphetamine has not been demonstrated to be effective, and studies of other pharmacologic agents are still preliminary. Future studies will incorporate refinements in clinical trial methods and improved activity- and technology-based interventions.
AB - Stroke rehabilitation is evolving into a clinical field based on the neuroscience of recovery and restoration. There has been substantial growth in the number and quality of clinical trials performed. Much effort now is directed toward motor restoration and is being led by trials of constraint-induced movement therapy. Although the results do not necessarily support that constraint-induced movement therapy is superior to other training methods, this treatment has become an important vehicle for developing clinical trial methods and studying the physiology underlying activity-based rehabilitation strategies. Other promising interventions include robotic therapy delivery, magnetic and electrical cortical stimulation, visualization, and constraint-driven aphasia therapies. Amphetamine has not been demonstrated to be effective, and studies of other pharmacologic agents are still preliminary. Future studies will incorporate refinements in clinical trial methods and improved activity- and technology-based interventions.
KW - Cerebrovascular disease
KW - Clinical trials
KW - Recovery
KW - Rehabilitation
UR - http://www.scopus.com/inward/record.url?scp=77954888751&partnerID=8YFLogxK
U2 - 10.1007/s11910-010-0091-9
DO - 10.1007/s11910-010-0091-9
M3 - Review article
C2 - 20425030
AN - SCOPUS:77954888751
SN - 1528-4042
VL - 10
SP - 158
EP - 166
JO - Current neurology and neuroscience reports
JF - Current neurology and neuroscience reports
IS - 3
ER -