TY - JOUR
T1 - Regulatory T cell-mediated transplantation tolerance
AU - Bharat, Ankit
AU - Fields, Ryan Courtney
AU - Mohanakumar, T.
N1 - Funding Information:
This work was supported by NIH HL56543 and HL66452 (T.M.). R.C.F. is a recipient of an ISHLT Research Fellowship Award and an AST Fellowship.
PY - 2005/12
Y1 - 2005/12
N2 - The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.
AB - The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.
KW - Adaptive immune response
KW - Antigen presentation
KW - Infectious tolerance
KW - Lung transplantation
KW - Regulatory cells
KW - T cells
KW - Transplantation tolerance
UR - http://www.scopus.com/inward/record.url?scp=32244438621&partnerID=8YFLogxK
U2 - 10.1385/IR:33:3:195
DO - 10.1385/IR:33:3:195
M3 - Review article
C2 - 16461998
AN - SCOPUS:32244438621
SN - 0257-277X
VL - 33
SP - 195
EP - 212
JO - Immunologic Research
JF - Immunologic Research
IS - 3
ER -