Regulatory T cell-mediated transplantation tolerance

Ankit Bharat, Ryan Courtney Fields, T. Mohanakumar

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.

Original languageEnglish
Pages (from-to)195-212
Number of pages18
JournalImmunologic Research
Issue number3
StatePublished - Dec 2005


  • Adaptive immune response
  • Antigen presentation
  • Infectious tolerance
  • Lung transplantation
  • Regulatory cells
  • T cells
  • Transplantation tolerance


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