Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function

Patrick Osei-Owusu; Kendall J. Blumer

doi:10.1016/bs.pmbts.2015.02.001

Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function

Patrick Osei-Owusu, Kendall J. Blumer

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

10 Scopus citations

Abstract

Regulators of G protein signaling (RGS) proteins of the B/R4 family are widely expressed in the cardiovascular system where their role in fine-tuning G protein signaling is critical to maintaining homeostasis. Among members of this family, RGS2 and RGS5 have been shown to play key roles in cardiac and smooth muscle function by tightly regulating signaling pathways that are activated through G_q/11 and G_i/o classes of heterotrimeric G proteins. This chapter reviews accumulating evidence supporting a key role for RGS2 in vascular function and the implication of changes in RGS2 function and/or expression in the pathogenesis of blood pressure disorders, particularly hypertension. With such understanding, RGS2 and the signaling pathways it controls may emerge as novel targets for developing next-generation antihypertensive drugs/agents.

Original language	English
Title of host publication	Progress in Molecular Biology and Translational Science
Publisher	Elsevier B.V.
Pages	77-92
Number of pages	16
DOIs	https://doi.org/10.1016/bs.pmbts.2015.02.001
State	Published - 2015

Publication series

Name	Progress in Molecular Biology and Translational Science
Volume	133
ISSN (Print)	1877-1173
ISSN (Electronic)	1878-0814

Keywords

Endothelium
G protein signaling
RGS2
Smooth muscle
Vascular function
Vasoactive hormones

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abstract = "Regulators of G protein signaling (RGS) proteins of the B/R4 family are widely expressed in the cardiovascular system where their role in fine-tuning G protein signaling is critical to maintaining homeostasis. Among members of this family, RGS2 and RGS5 have been shown to play key roles in cardiac and smooth muscle function by tightly regulating signaling pathways that are activated through Gq/11 and Gi/o classes of heterotrimeric G proteins. This chapter reviews accumulating evidence supporting a key role for RGS2 in vascular function and the implication of changes in RGS2 function and/or expression in the pathogenesis of blood pressure disorders, particularly hypertension. With such understanding, RGS2 and the signaling pathways it controls may emerge as novel targets for developing next-generation antihypertensive drugs/agents.",

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KW - Endothelium

KW - G protein signaling

KW - RGS2

KW - Smooth muscle

KW - Vascular function

KW - Vasoactive hormones

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PB - Elsevier B.V.

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Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function

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