Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C

Matthew A. Ciorba; Stefan H. Heinemann; Herbert Weissbach; Nathan Brot; Toshinori Hoshi

doi:10.1016/S0014-5793(98)01616-0

Regulation of voltage-dependent K⁺ channels by methionine oxidation: effect of nitric oxide and vitamin C

Matthew A. Ciorba, Stefan H. Heinemann, Herbert Weissbach, Nathan Brot, Toshinori Hoshi

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Methionine oxidation is known to alter functional properties of a transient A-type potassium channel expressed in Xenopus oocytes. We show here that nitric oxide (NO) slows down the K⁺ channel inactivation time course by oxidizing a critical methionine residue in the inactivation ball domain of the channel protein. We also demonstrate that the channel protein is protected from methionine oxidation by the enzyme methionine sulfoxide reductase and the antioxidant vitamin C. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	48-52
Number of pages	5
Journal	FEBS Letters
Volume	442
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(98)01616-0
State	Published - Jan 8 1999

Keywords

A-type potassium channel
Antioxidant
Methionine oxidation
Nitric oxide
Xenopus oocyte

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10.1016/S0014-5793(98)01616-0

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title = "Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C",

abstract = "Methionine oxidation is known to alter functional properties of a transient A-type potassium channel expressed in Xenopus oocytes. We show here that nitric oxide (NO) slows down the K+ channel inactivation time course by oxidizing a critical methionine residue in the inactivation ball domain of the channel protein. We also demonstrate that the channel protein is protected from methionine oxidation by the enzyme methionine sulfoxide reductase and the antioxidant vitamin C. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "A-type potassium channel, Antioxidant, Methionine oxidation, Nitric oxide, Xenopus oocyte",

author = "Ciorba, {Matthew A.} and Heinemann, {Stefan H.} and Herbert Weissbach and Nathan Brot and Toshinori Hoshi",

note = "Funding Information: We thank Dr. J. Thommandru and Ms. M. Masropour for technical assistance and F. King for inspiration. This work was in part supported by HFSP, DFG (He2993) and NIH GM57654.",

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T1 - Regulation of voltage-dependent K+ channels by methionine oxidation

T2 - effect of nitric oxide and vitamin C

AU - Ciorba, Matthew A.

AU - Heinemann, Stefan H.

AU - Weissbach, Herbert

AU - Brot, Nathan

AU - Hoshi, Toshinori

N1 - Funding Information: We thank Dr. J. Thommandru and Ms. M. Masropour for technical assistance and F. King for inspiration. This work was in part supported by HFSP, DFG (He2993) and NIH GM57654.

PY - 1999/1/8

Y1 - 1999/1/8

N2 - Methionine oxidation is known to alter functional properties of a transient A-type potassium channel expressed in Xenopus oocytes. We show here that nitric oxide (NO) slows down the K+ channel inactivation time course by oxidizing a critical methionine residue in the inactivation ball domain of the channel protein. We also demonstrate that the channel protein is protected from methionine oxidation by the enzyme methionine sulfoxide reductase and the antioxidant vitamin C. Copyright (C) 1999 Federation of European Biochemical Societies.

AB - Methionine oxidation is known to alter functional properties of a transient A-type potassium channel expressed in Xenopus oocytes. We show here that nitric oxide (NO) slows down the K+ channel inactivation time course by oxidizing a critical methionine residue in the inactivation ball domain of the channel protein. We also demonstrate that the channel protein is protected from methionine oxidation by the enzyme methionine sulfoxide reductase and the antioxidant vitamin C. Copyright (C) 1999 Federation of European Biochemical Societies.

KW - A-type potassium channel

KW - Antioxidant

KW - Methionine oxidation

KW - Nitric oxide

KW - Xenopus oocyte

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DO - 10.1016/S0014-5793(98)01616-0

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AN - SCOPUS:0032920132

SN - 0014-5793

VL - 442

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EP - 52

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

Regulation of voltage-dependent K⁺ channels by methionine oxidation: effect of nitric oxide and vitamin C

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