Regulation of the immune response by SHIP

Michael E. March; Kodi Ravichandran

doi:10.1006/smim.2001.0340

Regulation of the immune response by SHIP

Michael E. March, Kodi Ravichandran

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Multiple lines of experimental data indicate that SHIP1 is an important negative regulator of the immune system. SHIP1 has been demonstrated to control survival and proliferation, as well as differentiation. In the cases of some inhibitory receptors, such as Fcγ RIIB1, the molecular mechanisms of control by SHIP1 are established. For other receptors, particularly activating receptors where SHIP1 appears to set activation thresholds, the mechanisms remain to be discovered. Further study on SHIP and other SHIP family members could be critical for our understanding the negative regulation in multiple hematopoietic lineages and the immune system as a whole.

Original language	English
Pages (from-to)	37-47
Number of pages	11
Journal	Seminars in immunology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1006/smim.2001.0340
State	Published - 2002

Keywords

Fcγ
Inhibitory signaling
Inositol phosphatase
PIP
RIIB1
SHIP

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10.1006/smim.2001.0340

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title = "Regulation of the immune response by SHIP",

abstract = "Multiple lines of experimental data indicate that SHIP1 is an important negative regulator of the immune system. SHIP1 has been demonstrated to control survival and proliferation, as well as differentiation. In the cases of some inhibitory receptors, such as Fcγ RIIB1, the molecular mechanisms of control by SHIP1 are established. For other receptors, particularly activating receptors where SHIP1 appears to set activation thresholds, the mechanisms remain to be discovered. Further study on SHIP and other SHIP family members could be critical for our understanding the negative regulation in multiple hematopoietic lineages and the immune system as a whole.",

keywords = "Fcγ, Inhibitory signaling, Inositol phosphatase, PIP, RIIB1, SHIP",

author = "March, {Michael E.} and Kodi Ravichandran",

note = "Funding Information: We apologize to our colleagues whose work could not be cited due to space restrictions. M. M. was supported by a Cancer Training Grant from the National Institutes of Health. This work was supported in part by National Institutes of Health Grant A1-43425 (to KSR).",

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AU - Ravichandran, Kodi

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PY - 2002

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N2 - Multiple lines of experimental data indicate that SHIP1 is an important negative regulator of the immune system. SHIP1 has been demonstrated to control survival and proliferation, as well as differentiation. In the cases of some inhibitory receptors, such as Fcγ RIIB1, the molecular mechanisms of control by SHIP1 are established. For other receptors, particularly activating receptors where SHIP1 appears to set activation thresholds, the mechanisms remain to be discovered. Further study on SHIP and other SHIP family members could be critical for our understanding the negative regulation in multiple hematopoietic lineages and the immune system as a whole.

AB - Multiple lines of experimental data indicate that SHIP1 is an important negative regulator of the immune system. SHIP1 has been demonstrated to control survival and proliferation, as well as differentiation. In the cases of some inhibitory receptors, such as Fcγ RIIB1, the molecular mechanisms of control by SHIP1 are established. For other receptors, particularly activating receptors where SHIP1 appears to set activation thresholds, the mechanisms remain to be discovered. Further study on SHIP and other SHIP family members could be critical for our understanding the negative regulation in multiple hematopoietic lineages and the immune system as a whole.

KW - Fcγ

KW - Inhibitory signaling

KW - Inositol phosphatase

KW - PIP

KW - RIIB1

KW - SHIP

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AN - SCOPUS:0036196812

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VL - 14

SP - 37

EP - 47

JO - Seminars in immunology

JF - Seminars in immunology

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Regulation of the immune response by SHIP

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Keywords

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