Regulation of the Hippo pathway by cell architecture and mechanical signals

Molly C. Schroeder, Georg Halder

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations

Abstract

The Hippo signaling pathway is an evolutionarily conserved mediator of growth control, cell fate decisions and stem cell identity. At the heart of the pathway is a kinase cascade that is reminiscent of other signaling pathways, but recent studies indicate that the Hippo pathway is unique in that it is regulated by cellular architecture and the mechanical properties of the environment. The Hippo pathway may thus serve as a sensor of tissue structure and mechanical tension, integrating information regarding the size and shape of an organ into cellular behavior, such as whether or not to proliferate. In this review we summarize recent discoveries regarding the regulation of the Hippo pathway by cellular polarity, cell junctions, and the cytoskeleton and discuss how these data inform the study of development and disease.

Original languageEnglish
Pages (from-to)803-811
Number of pages9
JournalSeminars in Cell and Developmental Biology
Volume23
Issue number7
DOIs
StatePublished - Sep 2012

Keywords

  • Growth control
  • Mechanotransduction
  • Tumor suppressors

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