Regulation of the early development of the nervous system by growth factors

Perry F. Bartlett; Trevor J. Kilpatrick; Linda J. Richards; Paul S. Talman; Mark Murphy

doi:10.1016/0163-7258(94)00044-1

Regulation of the early development of the nervous system by growth factors

Perry F. Bartlett, Trevor J. Kilpatrick, Linda J. Richards, Paul S. Talman, Mark Murphy

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Development of the nervous system, although patterned by intrinsic genetic expression, appears to be dependent on growth factors for many of the differentiation steps that generate the wide variety of neurons and glia found in the both the central and peripheral nervous system. By using in vitro assays, including clonal analysis, the precise function of the various growth factors and the differentiation potential of the various neural populations has begun to be described. This review discusses some of the recent findings and examines how neuronal differentiation may result from the interaction of several growth factors.

Original language	English
Pages (from-to)	371-393
Number of pages	23
Journal	Pharmacology and Therapeutics
Volume	64
Issue number	3
DOIs	https://doi.org/10.1016/0163-7258(94)00044-1
State	Published - 1994

Keywords

Neural precursors
clonal analysis
fibroblast growth factors
lineage commitment
multipotentiality
neural crest

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10.1016/0163-7258(94)00044-1

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title = "Regulation of the early development of the nervous system by growth factors",

abstract = "Development of the nervous system, although patterned by intrinsic genetic expression, appears to be dependent on growth factors for many of the differentiation steps that generate the wide variety of neurons and glia found in the both the central and peripheral nervous system. By using in vitro assays, including clonal analysis, the precise function of the various growth factors and the differentiation potential of the various neural populations has begun to be described. This review discusses some of the recent findings and examines how neuronal differentiation may result from the interaction of several growth factors.",

keywords = "Neural precursors, clonal analysis, fibroblast growth factors, lineage commitment, multipotentiality, neural crest",

author = "Bartlett, {Perry F.} and Kilpatrick, {Trevor J.} and Richards, {Linda J.} and Talman, {Paul S.} and Mark Murphy",

note = "Funding Information: Acknowledgements--We wish to thank Kate Reid and Viki Likiardopoulos for much of the technical work described in work emanating from our laboratory, and the National Health and Medical Research Council of Australia, the Australian Medical Research and Development Corporation and the Cooperative Research Centre for Cellular Growth Factors for providing financial support.",

year = "1994",

doi = "10.1016/0163-7258(94)00044-1",

language = "English",

volume = "64",

pages = "371--393",

journal = "Pharmacology and Therapeutics",

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T1 - Regulation of the early development of the nervous system by growth factors

AU - Bartlett, Perry F.

AU - Kilpatrick, Trevor J.

AU - Richards, Linda J.

AU - Talman, Paul S.

AU - Murphy, Mark

N1 - Funding Information: Acknowledgements--We wish to thank Kate Reid and Viki Likiardopoulos for much of the technical work described in work emanating from our laboratory, and the National Health and Medical Research Council of Australia, the Australian Medical Research and Development Corporation and the Cooperative Research Centre for Cellular Growth Factors for providing financial support.

PY - 1994

Y1 - 1994

N2 - Development of the nervous system, although patterned by intrinsic genetic expression, appears to be dependent on growth factors for many of the differentiation steps that generate the wide variety of neurons and glia found in the both the central and peripheral nervous system. By using in vitro assays, including clonal analysis, the precise function of the various growth factors and the differentiation potential of the various neural populations has begun to be described. This review discusses some of the recent findings and examines how neuronal differentiation may result from the interaction of several growth factors.

AB - Development of the nervous system, although patterned by intrinsic genetic expression, appears to be dependent on growth factors for many of the differentiation steps that generate the wide variety of neurons and glia found in the both the central and peripheral nervous system. By using in vitro assays, including clonal analysis, the precise function of the various growth factors and the differentiation potential of the various neural populations has begun to be described. This review discusses some of the recent findings and examines how neuronal differentiation may result from the interaction of several growth factors.

KW - Neural precursors

KW - clonal analysis

KW - fibroblast growth factors

KW - lineage commitment

KW - multipotentiality

KW - neural crest

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DO - 10.1016/0163-7258(94)00044-1

M3 - Review article

C2 - 7724655

AN - SCOPUS:0027974146

SN - 0163-7258

VL - 64

SP - 371

EP - 393

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

IS - 3

ER -

Regulation of the early development of the nervous system by growth factors

Abstract

Keywords

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