Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease

You Jin Lee, Conrad C. Weihl

Research output: Contribution to journalComment/debate

18 Scopus citations

Abstract

Macroautophagy/autophagy can be a selective degradative process via the utilization of various autophagic receptor proteins. Autophagic receptors selectively recognize ubiquitinated cargoes and deliver them to phagophores, the precursors to autophagosomes, for their degradation. For example, SQSTM1/p62 directly binds to ubiquitinated protein aggregates via its UBA domain and sequesters them into inclusion bodies via its PB1 domain. SQSTM1also interacts with phagophores via its LC3-interacting (LIR) motif. However, a regulatory mechanism for autophagic receptors is not yet understood.

Original languageEnglish
Pages (from-to)1615-1616
Number of pages2
JournalAutophagy
Volume13
Issue number9
DOIs
StatePublished - Sep 2 2017

Keywords

  • Keap1-Cullin3-Nrf2 pathway
  • autophagy
  • neurodegenerative diseases
  • p62/SQSTM1
  • protein aggregates
  • ubiquitination

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