Regulation of NGF gene expression in CNS glia by cell-cell contact

Bai Lu, Jin Moo Lee, Robert Elliott, Cheryl F. Dreyfus, Joshua E. Adler, Ira B. Black

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Nerve growth factor (NGF) gene expression in central nervous system (CNS) glia appears to be associated with active glial growth. To study the underlying molecular mechanisms, we examined the effects of a number of growth-related factors on NGF mRNA expression in glial cultures. Our results suggest that glial membrane interaction, as a consequence of growth, actively inhibits NGF gene expression in CNS glia.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalMolecular Brain Research
Volume11
Issue number3-4
DOIs
StatePublished - Oct 1991

Keywords

  • Central nervous system glia
  • Development
  • High-density culture
  • Low-density culture
  • Membrane contact
  • Nerve growth factor
  • Rat brain
  • mRNA expression

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