Regulation of NGF gene expression in CNS glia by cell-cell contact

Bai Lu; Jin Moo Lee; Robert Elliott; Cheryl F. Dreyfus; Joshua E. Adler; Ira B. Black

doi:10.1016/0169-328X(91)90046-Z

Regulation of NGF gene expression in CNS glia by cell-cell contact

Bai Lu, Jin Moo Lee, Robert Elliott, Cheryl F. Dreyfus, Joshua E. Adler, Ira B. Black

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Nerve growth factor (NGF) gene expression in central nervous system (CNS) glia appears to be associated with active glial growth. To study the underlying molecular mechanisms, we examined the effects of a number of growth-related factors on NGF mRNA expression in glial cultures. Our results suggest that glial membrane interaction, as a consequence of growth, actively inhibits NGF gene expression in CNS glia.

Original language	English
Pages (from-to)	359-362
Number of pages	4
Journal	Molecular Brain Research
Volume	11
Issue number	3-4
DOIs	https://doi.org/10.1016/0169-328X(91)90046-Z
State	Published - Oct 1991

Keywords

Central nervous system glia
Development
High-density culture
Low-density culture
Membrane contact
Nerve growth factor
Rat brain
mRNA expression

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10.1016/0169-328X(91)90046-Z

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title = "Regulation of NGF gene expression in CNS glia by cell-cell contact",

abstract = "Nerve growth factor (NGF) gene expression in central nervous system (CNS) glia appears to be associated with active glial growth. To study the underlying molecular mechanisms, we examined the effects of a number of growth-related factors on NGF mRNA expression in glial cultures. Our results suggest that glial membrane interaction, as a consequence of growth, actively inhibits NGF gene expression in CNS glia.",

keywords = "Central nervous system glia, Development, High-density culture, Low-density culture, Membrane contact, Nerve growth factor, Rat brain, mRNA expression",

author = "Bai Lu and Lee, {Jin Moo} and Robert Elliott and Dreyfus, {Cheryl F.} and Adler, {Joshua E.} and Black, {Ira B.}",

year = "1991",

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AU - Lu, Bai

AU - Lee, Jin Moo

AU - Elliott, Robert

AU - Dreyfus, Cheryl F.

AU - Adler, Joshua E.

AU - Black, Ira B.

PY - 1991/10

Y1 - 1991/10

N2 - Nerve growth factor (NGF) gene expression in central nervous system (CNS) glia appears to be associated with active glial growth. To study the underlying molecular mechanisms, we examined the effects of a number of growth-related factors on NGF mRNA expression in glial cultures. Our results suggest that glial membrane interaction, as a consequence of growth, actively inhibits NGF gene expression in CNS glia.

AB - Nerve growth factor (NGF) gene expression in central nervous system (CNS) glia appears to be associated with active glial growth. To study the underlying molecular mechanisms, we examined the effects of a number of growth-related factors on NGF mRNA expression in glial cultures. Our results suggest that glial membrane interaction, as a consequence of growth, actively inhibits NGF gene expression in CNS glia.

KW - Central nervous system glia

KW - Development

KW - High-density culture

KW - Low-density culture

KW - Membrane contact

KW - Nerve growth factor

KW - Rat brain

KW - mRNA expression

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VL - 11

SP - 359

EP - 362

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 3-4

ER -

Regulation of NGF gene expression in CNS glia by cell-cell contact

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Keywords

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