Regulation of microglial survival and proliferation in health and diseases

Tyler K. Ulland; Yaming Wang; Marco Colonna

doi:10.1016/j.smim.2016.03.011

Regulation of microglial survival and proliferation in health and diseases

Tyler K. Ulland, Yaming Wang, Marco Colonna

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Microglia play an important role in the development and maintenance of the central nervous system (CNS) under homeostatic conditions as well as during neurodegenerative diseases. Recent observations in human genomics and advances in genetic mouse models have provided insights into signaling pathways that control development, survival, proliferation and function of microglia. Alteration of these pathways contributes to the pathogenesis of CNS diseases. Here we review the current literature regarding the roles of these microglial pathways in both the normal and diseased brain and discuss areas that require further investigation.

Original language	English
Pages (from-to)	410-415
Number of pages	6
Journal	Seminars in immunology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.smim.2016.03.011
State	Published - Dec 1 2015

Keywords

Alzheimer's
CSF-1
CSF-1R
Glioblastoma
IL-34
Microglia
Neurodegeneration
TREM2

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10.1016/j.smim.2016.03.011

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title = "Regulation of microglial survival and proliferation in health and diseases",

abstract = "Microglia play an important role in the development and maintenance of the central nervous system (CNS) under homeostatic conditions as well as during neurodegenerative diseases. Recent observations in human genomics and advances in genetic mouse models have provided insights into signaling pathways that control development, survival, proliferation and function of microglia. Alteration of these pathways contributes to the pathogenesis of CNS diseases. Here we review the current literature regarding the roles of these microglial pathways in both the normal and diseased brain and discuss areas that require further investigation.",

keywords = "Alzheimer's, CSF-1, CSF-1R, Glioblastoma, IL-34, Microglia, Neurodegeneration, TREM2",

author = "Ulland, {Tyler K.} and Yaming Wang and Marco Colonna",

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T1 - Regulation of microglial survival and proliferation in health and diseases

AU - Ulland, Tyler K.

AU - Wang, Yaming

AU - Colonna, Marco

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N2 - Microglia play an important role in the development and maintenance of the central nervous system (CNS) under homeostatic conditions as well as during neurodegenerative diseases. Recent observations in human genomics and advances in genetic mouse models have provided insights into signaling pathways that control development, survival, proliferation and function of microglia. Alteration of these pathways contributes to the pathogenesis of CNS diseases. Here we review the current literature regarding the roles of these microglial pathways in both the normal and diseased brain and discuss areas that require further investigation.

AB - Microglia play an important role in the development and maintenance of the central nervous system (CNS) under homeostatic conditions as well as during neurodegenerative diseases. Recent observations in human genomics and advances in genetic mouse models have provided insights into signaling pathways that control development, survival, proliferation and function of microglia. Alteration of these pathways contributes to the pathogenesis of CNS diseases. Here we review the current literature regarding the roles of these microglial pathways in both the normal and diseased brain and discuss areas that require further investigation.

KW - Alzheimer's

KW - CSF-1

KW - CSF-1R

KW - Glioblastoma

KW - IL-34

KW - Microglia

KW - Neurodegeneration

KW - TREM2

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DO - 10.1016/j.smim.2016.03.011

M3 - Review article

C2 - 27033414

AN - SCOPUS:84965179082

SN - 1044-5323

VL - 27

SP - 410

EP - 415

JO - Seminars in immunology

JF - Seminars in immunology

IS - 6

ER -

Regulation of microglial survival and proliferation in health and diseases

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Keywords

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