Regulation of metabolic supply and demand during B cell activation and subsequent differentiation

Takeshi Egawa, Deepta Bhattacharya

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

B cell activation and differentiation are associated with marked changes in proliferative and effector functions. Each stage of B cell differentiation thus has unique metabolic demands. New studies have provided insight on how nutrient uptake and usage by B cells are regulated by B cell receptor signals, autophagy, mammalian target of rapamycin, and transcriptional control of transporters and rate-limiting enzymes. A recurring theme is that these pathways play distinct roles ranging from survival to antibody production, depending on the B cell fate. We review recently published data that define how these pathways control metabolic flux in B cells, with a particular emphasis on genetic and in vivo evidence. We further discuss how lessons from T cells can guide future directions.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalCurrent Opinion in Immunology
Volume57
DOIs
StatePublished - Apr 2019

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