TY - JOUR
T1 - Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase
AU - Sakurai, Keisuke
AU - Chen, Jeannie
AU - Khani, Shahrokh C.
AU - Kefalov, Vladimir J.
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2015/4/3
Y1 - 2015/4/3
N2 - Background: Calcium-mediated feedback to phototransduction is critical for modulating cone responses under different lighting conditions. Results: The calcium-binding protein recoverin potentiates dim light sensitivity, whereas increasing expression of its target, GRK1, delays response shutoff in cones. Conclusion: Recoverin and GRK1 levels modulate cone phototransduction. Significance: Cone pigment inactivation regulates cone responses in dim light but not in bright light.
AB - Background: Calcium-mediated feedback to phototransduction is critical for modulating cone responses under different lighting conditions. Results: The calcium-binding protein recoverin potentiates dim light sensitivity, whereas increasing expression of its target, GRK1, delays response shutoff in cones. Conclusion: Recoverin and GRK1 levels modulate cone phototransduction. Significance: Cone pigment inactivation regulates cone responses in dim light but not in bright light.
UR - http://www.scopus.com/inward/record.url?scp=84928911301&partnerID=8YFLogxK
U2 - 10.1074/jbc.M115.639591
DO - 10.1074/jbc.M115.639591
M3 - Article
C2 - 25673692
AN - SCOPUS:84928911301
SN - 0021-9258
VL - 290
SP - 9239
EP - 9250
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 14
ER -