Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase

Keisuke Sakurai, Jeannie Chen, Shahrokh C. Khani, Vladimir J. Kefalov

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Calcium-mediated feedback to phototransduction is critical for modulating cone responses under different lighting conditions. Results: The calcium-binding protein recoverin potentiates dim light sensitivity, whereas increasing expression of its target, GRK1, delays response shutoff in cones. Conclusion: Recoverin and GRK1 levels modulate cone phototransduction. Significance: Cone pigment inactivation regulates cone responses in dim light but not in bright light.

Original languageEnglish
Pages (from-to)9239-9250
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number14
DOIs
StatePublished - Apr 3 2015

Fingerprint Dive into the research topics of 'Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase'. Together they form a unique fingerprint.

  • Cite this