Regulation of long-range planar cell polarity by Fat- Dachsous signaling

Praveer Sharma, Helen McNeill

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Fat (Ft) and Dachsous (Ds) are large cadherins that bind each other and have conserved roles in regulating planar cell polarity (PCP). We quantitatively analyzed Ft-Ds pathway mutant clones for their effects on ommatidial polarity in the Drosophila eye. Our findings suggest that the Ft-Ds pathway regulates PCP propagation independently of asymmetric cellular accumulation of Ft or Ds. We find that the Ft effector Atrophin has a position-specific role in regulating polarity in the eye, and that asymmetric accumulation of the atypical myosin Dachs is not essential for production and propagation of a long-range PCP signal. Our observations suggest that Ft and Ds interact to modulate a secondary signal that regulates long-range polarity, that signaling by the Ds intracellular domain is dependent on Ft, and that ommatidial fate specification is genetically separable from long-range signaling.

Original languageEnglish
Pages (from-to)3869-3881
Number of pages13
JournalDevelopment (Cambridge)
Volume140
Issue number18
DOIs
StatePublished - Sep 15 2013

Keywords

  • Atrophin
  • Dachsous
  • Drosophila
  • Fat
  • PCP
  • Polarity

Fingerprint

Dive into the research topics of 'Regulation of long-range planar cell polarity by Fat- Dachsous signaling'. Together they form a unique fingerprint.

Cite this