Regulation of immunity and disease by the IL-1 receptor family members IL-1R2 and IL-1R8

Martina Molgora, Domenico Supino, Cecilia Garlanda

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Interleukin-1 and other IL-1 family members are key players in immunity and inflammation. The activation of the IL-1 system is tightly regulated, through ligands with antagonistic or anti-inflammatory activity, or decoy and negative regulatory receptors. IL-1R2 and IL-1R8 (also known as SIGIRR) are members of the ILR family acting as negative regulators of the IL-1 system. IL-1R2 binds IL-1 and the accessory protein IL-1RAcP without activating signaling, thus modulating IL-1 availability for the signaling receptor. IL-1R8 dampens IL-1 receptor- and Toll Like Receptor-mediated cell activation and is a component of the receptor complex recognizing the anti-inflammatory cytokine IL-37. The deregulated activation of the IL-1 system is the potential cause of detrimental local or systemic inflammatory reactions. Here, we summarize our current understanding of the function of IL-1R2 and IL-1R8, focusing on their role in pathological conditions, ranging from infectious and sterile inflammation, to cancer-related inflammation.

Original languageEnglish
Title of host publicationImmunopharmacology and Inflammation
PublisherSpringer International Publishing
Number of pages21
ISBN (Electronic)9783319776583
ISBN (Print)9783319776576
StatePublished - Jun 9 2018


  • Infection
  • Inflammation
  • Inflammation-associated cancer
  • Interleukin-1


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