Regulation of Human Immunodeficiency Virus Nef Protein by Phosphorylation

J. C. Bandres, S. Luria, L. Ratner

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Human immunodeficiency virus isolates express a Nef protein with either an alanine or a threonine at amino acid residue 15. The threonine residue is a site for phosphorylation by protein kinase C. Jurkat T cells constitutively expressing the alanine variant of Nef exhibit the ability to downregulate the induction of transcription factors NF-kB and AP-1. In contrast, Jurkat cells with the threonine variant of Nef are at least partially restored in their ability to recruit NF-kB and AP-1.

Original languageEnglish
Article number71278
Pages (from-to)157-161
Number of pages5
JournalVirology
Volume201
Issue number1
DOIs
StatePublished - May 15 1994

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