Abstract
Human immunodeficiency virus isolates express a Nef protein with either an alanine or a threonine at amino acid residue 15. The threonine residue is a site for phosphorylation by protein kinase C. Jurkat T cells constitutively expressing the alanine variant of Nef exhibit the ability to downregulate the induction of transcription factors NF-kB and AP-1. In contrast, Jurkat cells with the threonine variant of Nef are at least partially restored in their ability to recruit NF-kB and AP-1.
Original language | English |
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Article number | 71278 |
Pages (from-to) | 157-161 |
Number of pages | 5 |
Journal | Virology |
Volume | 201 |
Issue number | 1 |
DOIs | |
State | Published - May 15 1994 |