Abstract
Human immunodeficiency virus isolates express a Nef protein with either an alanine or a threonine at amino acid residue 15. The threonine residue is a site for phosphorylation by protein kinase C. Jurkat T cells constitutively expressing the alanine variant of Nef exhibit the ability to downregulate the induction of transcription factors NF-kB and AP-1. In contrast, Jurkat cells with the threonine variant of Nef are at least partially restored in their ability to recruit NF-kB and AP-1.
| Original language | English |
|---|---|
| Article number | 71278 |
| Pages (from-to) | 157-161 |
| Number of pages | 5 |
| Journal | Virology |
| Volume | 201 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 15 1994 |
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Bandres, J. C., Luria, S., & Ratner, L. (1994). Regulation of Human Immunodeficiency Virus Nef Protein by Phosphorylation. Virology, 201(1), 157-161. [71278]. https://doi.org/10.1006/viro.1994.1278