Regulation of hematopoiesis by cxcl12/cxcr4 signaling

Daniel C. Link

doi:10.1007/978-1-4939-1393-0_30

Regulation of hematopoiesis by cxcl12/cxcr4 signaling

Daniel C. Link

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Scopus citations

Abstract

CXCL12 (stromal-derived factor 1, SDF-1) is a chemokine that is constitutively expressed at high levels in the bone marrow and is a key component of the stem cell niche. Its major receptor CXCR4 is broadly expressed on hematopoietic cells, including hematopoietic stem cells (HSCs). The CXCL12/CXCR4 axis plays a key role in regulating many aspects of hematopoiesis. It is essential for normal B-cell lymphopoiesis and is a key determinant of neutrophil release from the bone marrow. Activating mutations of CXCR4 are causative of the warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, which is characterized by abnormal neutrophil retention in the bone marrow and impaired B-cell development. The CXCL12/CXCR4 axis also plays an essential role in HSC maintenance and trafficking, and pharmaceuticals that inhibit CXCR4 signaling result in rapid mobilization.

Original language	English
Title of host publication	Targeted Therapy of Acute Myeloid Leukemi
Publisher	Springer New York
Pages	593-605
Number of pages	13
ISBN (Electronic)	9781493913930
ISBN (Print)	9781493913923
DOIs	https://doi.org/10.1007/978-1-4939-1393-0_30
State	Published - Jan 1 2015

Keywords

B-cell lymphopoiesis
CXCL12
CXCR4
Hematopoietic stem cells
Mobilization
Quiescence
Stem cell niche
Stromal-derived factor 1

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10.1007/978-1-4939-1393-0_30

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title = "Regulation of hematopoiesis by cxcl12/cxcr4 signaling",

abstract = "CXCL12 (stromal-derived factor 1, SDF-1) is a chemokine that is constitutively expressed at high levels in the bone marrow and is a key component of the stem cell niche. Its major receptor CXCR4 is broadly expressed on hematopoietic cells, including hematopoietic stem cells (HSCs). The CXCL12/CXCR4 axis plays a key role in regulating many aspects of hematopoiesis. It is essential for normal B-cell lymphopoiesis and is a key determinant of neutrophil release from the bone marrow. Activating mutations of CXCR4 are causative of the warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, which is characterized by abnormal neutrophil retention in the bone marrow and impaired B-cell development. The CXCL12/CXCR4 axis also plays an essential role in HSC maintenance and trafficking, and pharmaceuticals that inhibit CXCR4 signaling result in rapid mobilization.",

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N2 - CXCL12 (stromal-derived factor 1, SDF-1) is a chemokine that is constitutively expressed at high levels in the bone marrow and is a key component of the stem cell niche. Its major receptor CXCR4 is broadly expressed on hematopoietic cells, including hematopoietic stem cells (HSCs). The CXCL12/CXCR4 axis plays a key role in regulating many aspects of hematopoiesis. It is essential for normal B-cell lymphopoiesis and is a key determinant of neutrophil release from the bone marrow. Activating mutations of CXCR4 are causative of the warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, which is characterized by abnormal neutrophil retention in the bone marrow and impaired B-cell development. The CXCL12/CXCR4 axis also plays an essential role in HSC maintenance and trafficking, and pharmaceuticals that inhibit CXCR4 signaling result in rapid mobilization.

AB - CXCL12 (stromal-derived factor 1, SDF-1) is a chemokine that is constitutively expressed at high levels in the bone marrow and is a key component of the stem cell niche. Its major receptor CXCR4 is broadly expressed on hematopoietic cells, including hematopoietic stem cells (HSCs). The CXCL12/CXCR4 axis plays a key role in regulating many aspects of hematopoiesis. It is essential for normal B-cell lymphopoiesis and is a key determinant of neutrophil release from the bone marrow. Activating mutations of CXCR4 are causative of the warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, which is characterized by abnormal neutrophil retention in the bone marrow and impaired B-cell development. The CXCL12/CXCR4 axis also plays an essential role in HSC maintenance and trafficking, and pharmaceuticals that inhibit CXCR4 signaling result in rapid mobilization.

KW - B-cell lymphopoiesis

KW - CXCL12

KW - CXCR4

KW - Hematopoietic stem cells

KW - Mobilization

KW - Quiescence

KW - Stem cell niche

KW - Stromal-derived factor 1

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BT - Targeted Therapy of Acute Myeloid Leukemi

PB - Springer New York

ER -

Regulation of hematopoiesis by cxcl12/cxcr4 signaling

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Keywords

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