Regulation of hematopoiesis by cxcl12/cxcr4 signaling

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

CXCL12 (stromal-derived factor 1, SDF-1) is a chemokine that is constitutively expressed at high levels in the bone marrow and is a key component of the stem cell niche. Its major receptor CXCR4 is broadly expressed on hematopoietic cells, including hematopoietic stem cells (HSCs). The CXCL12/CXCR4 axis plays a key role in regulating many aspects of hematopoiesis. It is essential for normal B-cell lymphopoiesis and is a key determinant of neutrophil release from the bone marrow. Activating mutations of CXCR4 are causative of the warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, which is characterized by abnormal neutrophil retention in the bone marrow and impaired B-cell development. The CXCL12/CXCR4 axis also plays an essential role in HSC maintenance and trafficking, and pharmaceuticals that inhibit CXCR4 signaling result in rapid mobilization.

Original languageEnglish
Title of host publicationTargeted Therapy of Acute Myeloid Leukemi
PublisherSpringer New York
Pages593-605
Number of pages13
ISBN (Electronic)9781493913930
ISBN (Print)9781493913923
DOIs
StatePublished - Jan 1 2015

Keywords

  • B-cell lymphopoiesis
  • CXCL12
  • CXCR4
  • Hematopoietic stem cells
  • Mobilization
  • Quiescence
  • Stem cell niche
  • Stromal-derived factor 1

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  • Cite this

    Link, D. C. (2015). Regulation of hematopoiesis by cxcl12/cxcr4 signaling. In Targeted Therapy of Acute Myeloid Leukemi (pp. 593-605). Springer New York. https://doi.org/10.1007/978-1-4939-1393-0_30