TY - CHAP
T1 - Regulation of glucose transport by nonsteroidal anti-inflammatory drugs
AU - Mobasheri, Ali
AU - Bondy, Carolyn A.
AU - Moley, Kelle
AU - Mendes, Alexandrina Ferreira
AU - Rosa, Susana Carvalho
AU - Richardson, Stephen M.
AU - Hoyland, Judith A.
AU - Barrett-Jolley, Richard
AU - Shakibaei, Mehdi
PY - 2008
Y1 - 2008
N2 - Cartilage destruction in arthritis and OA is linked to aberrant proinflammatory cytokine and growth factor expression in the joint (Chikanza and Fernandes 2000; Malemud et al. 2003). The proinflammatory cytokines TNF-α and IL-β have been found in significantly elevated levels in the synovial fluid of OA joints (Goldring 1999, 2000a; van den Berg 1999). Catabolic pathways are activated by TNF-α and IL-β, which are both upregulated in OA (Malemud et al. 2003). These proinflammatory mediators cause an increase in cartilage matrix degradation through increased MMP and aggrecanase activity in the joint. In addition, TNF-α and IL-β downregulate ECM protein biosynthesis while concomitantly up-regulating matrix MMP gene and protein expression. When MMPs are activated, cartilage ECM degradation ensues apparently because levels of endogenous cartilage MMP inhibitors cannot regulate MMP activity (Malemud et al. 2003).
AB - Cartilage destruction in arthritis and OA is linked to aberrant proinflammatory cytokine and growth factor expression in the joint (Chikanza and Fernandes 2000; Malemud et al. 2003). The proinflammatory cytokines TNF-α and IL-β have been found in significantly elevated levels in the synovial fluid of OA joints (Goldring 1999, 2000a; van den Berg 1999). Catabolic pathways are activated by TNF-α and IL-β, which are both upregulated in OA (Malemud et al. 2003). These proinflammatory mediators cause an increase in cartilage matrix degradation through increased MMP and aggrecanase activity in the joint. In addition, TNF-α and IL-β downregulate ECM protein biosynthesis while concomitantly up-regulating matrix MMP gene and protein expression. When MMPs are activated, cartilage ECM degradation ensues apparently because levels of endogenous cartilage MMP inhibitors cannot regulate MMP activity (Malemud et al. 2003).
UR - http://www.scopus.com/inward/record.url?scp=51049111460&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-78899-7_8
DO - 10.1007/978-3-540-78899-7_8
M3 - Chapter
AN - SCOPUS:51049111460
SN - 9783540788980
T3 - Advances in Anatomy Embryology and Cell Biology
SP - 50
EP - 53
BT - Facilitative Glucose Transporters in Articular Chondrocytes
A2 - Mobasheri, Ali
A2 - Bondy, Carolyn
A2 - Moley, Kelle
A2 - Ferreira Mendes, Alexandrina
A2 - Carvalho Rosa, Susana
A2 - Richardson, Stephen
A2 - Hoyland, Judith
A2 - Barrett-Jolley, Richard
A2 - Shakibaei, Mehdi
ER -