TY - JOUR
T1 - Regulation of dendrite morphogenesis by extrinsic cues
AU - Valnegri, Pamela
AU - Puram, Sidharth V.
AU - Bonni, Azad
N1 - Funding Information:
This work was supported by the National Institutes of Health grant NS084393 (to A.B.) and by the European Molecular Biology Organization (ALTF 889-2011 to P.V.). We thank members of the laboratory of A.B. for helpful discussions and critical reading of the manuscript.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Dendrites play a central role in the integration and flow of information in the nervous system. The morphogenesis and maturation of dendrites is hence an essential step in the establishment of neuronal connectivity. Recent studies have uncovered crucial functions for extrinsic cues in the development of dendrites. We review the contribution of secreted polypeptide growth factors, contact-mediated proteins, and neuronal activity in distinct phases of dendrite development. We also highlight how extrinsic cues influence local and global intracellular mechanisms of dendrite morphogenesis. Finally, we discuss how these studies have advanced our understanding of neuronal connectivity and have shed light on the pathogenesis of neurodevelopmental disorders.
AB - Dendrites play a central role in the integration and flow of information in the nervous system. The morphogenesis and maturation of dendrites is hence an essential step in the establishment of neuronal connectivity. Recent studies have uncovered crucial functions for extrinsic cues in the development of dendrites. We review the contribution of secreted polypeptide growth factors, contact-mediated proteins, and neuronal activity in distinct phases of dendrite development. We also highlight how extrinsic cues influence local and global intracellular mechanisms of dendrite morphogenesis. Finally, we discuss how these studies have advanced our understanding of neuronal connectivity and have shed light on the pathogenesis of neurodevelopmental disorders.
KW - Calcium signaling
KW - Contact-mediated regulators
KW - Dendrite morphogenesis
KW - Neuronal activity
KW - Secreted polypeptide growth factors
UR - http://www.scopus.com/inward/record.url?scp=84933676232&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2015.05.003
DO - 10.1016/j.tins.2015.05.003
M3 - Review article
C2 - 26100142
AN - SCOPUS:84933676232
SN - 0166-2236
VL - 38
SP - 439
EP - 447
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 7
ER -