Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

Maureen Wirschell; Ryosuke Yamamoto; Lea Alford; Avanti Gokhale; Anne Gaillard; Winfield S. Sale

doi:10.1016/j.abb.2011.04.003

Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

Maureen Wirschell
, Ryosuke Yamamoto
, Lea Alford
, Avanti Gokhale
, Anne Gaillard
, Winfield S. Sale

Department of Genetics

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

Original language	English
Pages (from-to)	93-100
Number of pages	8
Journal	Archives of Biochemistry and Biophysics
Volume	510
Issue number	2
DOIs	https://doi.org/10.1016/j.abb.2011.04.003
State	Published - Jun 15 2011

Keywords

Axoneme
Cilia
Flagella
Kinases
Phosphatases

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10.1016/j.abb.2011.04.003

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title = "Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme",

abstract = "Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.",

keywords = "Axoneme, Cilia, Flagella, Kinases, Phosphatases",

author = "Maureen Wirschell and Ryosuke Yamamoto and Lea Alford and Avanti Gokhale and Anne Gaillard and Sale, \{Winfield S.\}",

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T1 - Regulation of ciliary motility

T2 - Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

AU - Wirschell, Maureen

AU - Yamamoto, Ryosuke

AU - Alford, Lea

AU - Gokhale, Avanti

AU - Gaillard, Anne

AU - Sale, Winfield S.

PY - 2011/6/15

Y1 - 2011/6/15

N2 - Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

AB - Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

KW - Axoneme

KW - Cilia

KW - Flagella

KW - Kinases

KW - Phosphatases

UR - https://www.scopus.com/pages/publications/79958717871

U2 - 10.1016/j.abb.2011.04.003

DO - 10.1016/j.abb.2011.04.003

M3 - Review article

C2 - 21513695

AN - SCOPUS:79958717871

SN - 0003-9861

VL - 510

SP - 93

EP - 100

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

IS - 2

ER -

Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

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Keywords

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