Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

Maureen Wirschell, Ryosuke Yamamoto, Lea Alford, Avanti Gokhale, Anne Gaillard, Winfield S. Sale

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume510
Issue number2
DOIs
StatePublished - Jun 15 2011

Keywords

  • Axoneme
  • Cilia
  • Flagella
  • Kinases
  • Phosphatases

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