Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

Maureen Wirschell; Ryosuke Yamamoto; Lea Alford; Avanti Gokhale; Anne Gaillard; Winfield S. Sale

doi:10.1016/j.abb.2011.04.003

Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

Maureen Wirschell, Ryosuke Yamamoto, Lea Alford, Avanti Gokhale, Anne Gaillard, Winfield S. Sale

Department of Genetics

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

Original language	English
Pages (from-to)	93-100
Number of pages	8
Journal	Archives of Biochemistry and Biophysics
Volume	510
Issue number	2
DOIs	https://doi.org/10.1016/j.abb.2011.04.003
State	Published - Jun 15 2011

Keywords

Axoneme
Cilia
Flagella
Kinases
Phosphatases

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10.1016/j.abb.2011.04.003

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abstract = "Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.",

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AU - Wirschell, Maureen

AU - Yamamoto, Ryosuke

AU - Alford, Lea

AU - Gokhale, Avanti

AU - Gaillard, Anne

AU - Sale, Winfield S.

PY - 2011/6/15

Y1 - 2011/6/15

N2 - Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

AB - Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9 + 2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

KW - Axoneme

KW - Cilia

KW - Flagella

KW - Kinases

KW - Phosphatases

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U2 - 10.1016/j.abb.2011.04.003

DO - 10.1016/j.abb.2011.04.003

M3 - Review article

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EP - 100

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

IS - 2

ER -

Regulation of ciliary motility: Conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme

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Keywords

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