Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein

Sandhya Payankaulam, Kelvin Yeung, Helen McNeill, R. William Henry, David N. Arnosti

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In addition to their canonical roles in the cell cycle, RB family proteins regulate numerous developmental pathways, although the mechanisms remain obscure. We found that Drosophila Rbf1 associates with genes encoding components of the highly conserved apical-basal and planar cell polarity pathways, suggesting a possible regulatory role. Here, we show that depletion of Rbf1 in Drosophila tissues is indeed associated with polarity defects in the wing and eye. Key polarity genes aPKC, par6, vang, pk, and fmi are upregulated, and an aPKC mutation suppresses the Rbf1-induced phenotypes. RB control of cell polarity may be an evolutionarily conserved function, with important implications in cancer metastasis.

Original languageEnglish
Article number22879
JournalScientific reports
Volume6
DOIs
StatePublished - Mar 14 2016

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