37 Scopus citations

Abstract

Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation, migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies including glaucoma and hypertensive fibrotic remodeling. In this review, recent advances in quantifying and predicting how cells respond to HP across several tissue systems are presented, including tissues of the brain, eye, vasculature and bladder, as well as articular cartilage. Finally, some promising directions on the study of cell behaviors regulated by HP are proposed.

Original languageEnglish
Article number040803
JournalApplied Mechanics Reviews
Volume71
Issue number4
DOIs
StatePublished - Jul 2019

Keywords

  • Cell micro-environment
  • Cell volume
  • Mechanobiology
  • Mechanotransduction

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