Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conservation in the motor and light chain-binding domains (LCBDs) of these myosins, recent studies have revealed surprising diversity of function and regulation arising from isoform-specific differences in these domains. Here we review the regulation of myosin-I function and localization by the motor and LCBDs.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalTrends in Cell Biology
Issue number2
StatePublished - Feb 2013


  • Light chain-binding domain
  • Mechanochemistry
  • Motor domain
  • Myosin-I


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