Regramming myeloid responses to improve cancer immunotherapy

Yu Zhu; William G. Hawkins; David G. Denardo

doi:10.4161/2162402X.2014.974399

Regramming myeloid responses to improve cancer immunotherapy

Yu Zhu, William G. Hawkins, David G. Denardo

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Infiltration by immunosuppressive myeloid cells helps tumors to overcome immune surveillance and can render patients less responsive to therapeutic intervention. Several recent studies have demonstrated that reprogramming myeloid responses can effectively enhance cancer immunotherapy, suggesting several new potential combination therapies for clinical testing.

Original language	English
Journal	OncoImmunology
Volume	4
Issue number	6
DOIs	https://doi.org/10.4161/2162402X.2014.974399
State	Published - Jan 1 2015

Keywords

Cancer immunotherapy
Immune checkpoints
MDSCs
Macrophages
PD-1

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10.4161/2162402X.2014.974399

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title = "Regramming myeloid responses to improve cancer immunotherapy",

abstract = "Infiltration by immunosuppressive myeloid cells helps tumors to overcome immune surveillance and can render patients less responsive to therapeutic intervention. Several recent studies have demonstrated that reprogramming myeloid responses can effectively enhance cancer immunotherapy, suggesting several new potential combination therapies for clinical testing.",

keywords = "Cancer immunotherapy, Immune checkpoints, MDSCs, Macrophages, PD-1",

author = "Yu Zhu and Hawkins, {William G.} and Denardo, {David G.}",

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AU - Denardo, David G.

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KW - Immune checkpoints

KW - MDSCs

KW - Macrophages

KW - PD-1

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Regramming myeloid responses to improve cancer immunotherapy

Abstract

Keywords

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