Registration of medical images using an interpolated closest point transform: Method and validation

Zhujiang Cao, Shiyan Pan, Rui Li, Ramya Balachandran, Michael J. Fitzpatrick, William C. Chapman, Benoit M. Dawant

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations


Image registration is an important procedure for medical diagnosis. Since the large inter-site retrospective validation study led by Fitzpatrick at Vanderbilt University, voxel-based methods and more specifically mutual information (MI) based registration methods have been regarded as the method of choice for rigid-body intra-subject registration problems. In this study we propose a method that is based on the iterative closest point (ICP) algorithm and a pre-computed closest point map obtained with a slight modification of the fast marching method proposed by Sethian. We also propose an interpolation scheme that allows us to find the corresponding points with a sub-voxel accuracy even though the closest point map is defined on a regular grid. The method has been tested both on synthetic and real images and registration results have been assessed quantitatively using the data set provided by the Retrospective Registration Evaluation Project. For these volumes, MR and CT head surfaces were extracted automatically using a level-set technique. Results show that on these data sets this registration method leads to accuracy numbers that are comparable to those obtained with voxel-based methods.

Original languageEnglish
Pages (from-to)325-333
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5032 I
StatePublished - 2003
EventMedical Imaging 2003: Image Processing - San Diego, CA, United States
Duration: Feb 17 2003Feb 20 2003


  • Closest feature transform
  • Distance transform
  • Fast marching method
  • Surface-based registration


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