Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: The synthesis of 2-substituted 5-bromobenzoic acids

Karsten Menzel; Lisa Dimichele; Paul Mills; Doug E. Frantz; Todd D. Nelson; Michael H. Kress

doi:10.1055/s-2006-947362

Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: The synthesis of 2-substituted 5-bromobenzoic acids

Karsten Menzel
, Lisa Dimichele
, Paul Mills
, Doug E. Frantz
, Todd D. Nelson
, Michael H. Kress

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Regioselective halogen-metal exchange reactions using isopropylmagnesium chloride were carried out on 3-substituted 1,2-dibromo arenes. Eleven examples are given.

Original language	English
Pages (from-to)	1948-1952
Number of pages	5
Journal	Synlett
Issue number	12
DOIs	https://doi.org/10.1055/s-2006-947362
State	Published - Aug 1 2006

Keywords

1,2-dibromobenzene
Carboxylic acids
Grignard reactions
Regioselectivity
Substitutent effect

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10.1055/s-2006-947362

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title = "Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: The synthesis of 2-substituted 5-bromobenzoic acids",

abstract = "Regioselective halogen-metal exchange reactions using isopropylmagnesium chloride were carried out on 3-substituted 1,2-dibromo arenes. Eleven examples are given.",

keywords = "1,2-dibromobenzene, Carboxylic acids, Grignard reactions, Regioselectivity, Substitutent effect",

author = "Karsten Menzel and Lisa Dimichele and Paul Mills and Frantz, \{Doug E.\} and Nelson, \{Todd D.\} and Kress, \{Michael H.\}",

year = "2006",

month = aug,

day = "1",

doi = "10.1055/s-2006-947362",

language = "English",

pages = "1948--1952",

journal = "Synlett",

issn = "0936-5214",

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T1 - Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes

T2 - The synthesis of 2-substituted 5-bromobenzoic acids

AU - Menzel, Karsten

AU - Dimichele, Lisa

AU - Mills, Paul

AU - Frantz, Doug E.

AU - Nelson, Todd D.

AU - Kress, Michael H.

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Regioselective halogen-metal exchange reactions using isopropylmagnesium chloride were carried out on 3-substituted 1,2-dibromo arenes. Eleven examples are given.

AB - Regioselective halogen-metal exchange reactions using isopropylmagnesium chloride were carried out on 3-substituted 1,2-dibromo arenes. Eleven examples are given.

KW - 1,2-dibromobenzene

KW - Carboxylic acids

KW - Grignard reactions

KW - Regioselectivity

KW - Substitutent effect

UR - https://www.scopus.com/pages/publications/33747056348

U2 - 10.1055/s-2006-947362

DO - 10.1055/s-2006-947362

M3 - Article

AN - SCOPUS:33747056348

SN - 0936-5214

SP - 1948

EP - 1952

JO - Synlett

JF - Synlett

IS - 12

ER -

Regioselective halogen-metal exchange reaction of 3-substituted 1,2-dibromo arenes: The synthesis of 2-substituted 5-bromobenzoic acids

Abstract

Keywords

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