Abstract
Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 792-809 |
| Number of pages | 18 |
| Journal | Human Brain Mapping |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2014 |
Keywords
- Diffeomorphic mapping
- Pallidus atrophy
- Striatal atrophy
- Surface registration
- Surface-based morphometry
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Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis. / Younes, Laurent; Ratnanather, J. Tilak; Brown, Timothy; Aylward, Elizabeth; Nopoulos, Peg; Johnson, Hans; Magnotta, Vincent A.; Paulsen, Jane S.; Margolis, Russell L.; Albin, Roger L.; Miller, Michael I.; Ross, Christopher A.; Wassink, Thomas; Cross, Stephen; Kimble, Mycah; Ryan, Patricia; Epping, Eric A.; Chiu, Edmond; Yastrubetskaya, Olga; Preston, Joy; Goh, Anita; Psych, D.; Antonopoulos, Stephanie; Loi, Samantha; Chua, Phyllis; Komiti, Angela; Raymond, Lynn; Decolongon, Joji; Varvaris, Mark; Mallonee, William M.; Suter, Greg; Samii, Ali; Macaraeg, Alma; Jones, Randi; Wood-Siverio, Cathy; Factor, Stewart A.; Testa, Claudia; Barker, Roger A.; Mason, Sarah; McCusker, Elizabeth; Griffith, Jane; Loy, Clement; Gunn, David; Orth, Michael; Sübmuth, Sigurd; Barth, Katrin; Trautmann, Sonja; Quaid, Kimberly; Wesson, Melissa; Wojcieszek, Joanne; Guttman, Mark; Sheinberg, Alanna; Karmalkar, Irita; Perlman, Susan; Clemente, Brian; Geschwind, Michael D.; Kang, Gail; Satris, Gabriela; Warner, Tom; Burrows, Maggie; Rosser, Anne; Price, Kathy; Hunt, Sarah; Marshall, Frederick; Chesire, Amy; Wodarski, Mary; Hickey, Charlyne; Panegyres, Peter; Lee, Joseph; Andrew, Steve; Perlmutter, Joel; Barton, Stacey; Schmidt, Amy; Miedzybrodzka, Zosia; Rae, Daniela; D'Alessandro, Mariella; Craufurd, David; Bek, Judith; Howard, Elizabeth; Mazzoni, Pietro; Marder, Karen; Wasserman, Paula; Kumar, Rajeev; Erickson, Diane; Wheelock, Vicki; Tempkin, Terry; Kjer, Lisa; Martin, Wayne; King, Pamela; Wieler, Marguerite; Sran, Satwinder; Suchowersky, Oksana; Ahmed, Anwar; Rao, Stephen; Reece, Christine; Bura, Alex; Mourany, Lyla; Schulz, Juliet; Long, Jeffrey D.; Montross, Kelsey; Bockholt, Jeremy; Blanchard, Steve; Evans, Ken; Matson, Wayne; Peterson, Asa; Mills, James A.; Vonsattel, Jean Paul; Moskowitz, Carol; Vik, Stacie; Harrington, Deborah; Castillo, Gabriel; Morison, Jessica; Reed, Jason; Diaz, Michael; Dobbins, Ian; Hershey, Tamara; Foster, Erin; Moore, Deborah; Westervelt, Holly; Davis, Jennifer; Tremont, Geoff; David, J.; Gehl, Carissa; Matheson, Kirsty; Siedlecki, Karen; Walsem, Marleen Van; Elias, Greg; Gover, Mary; Bernier, Rachel; Carlozzi, Noelle; Duff, Kevin; Nellie Georgiou-Karistianis, Georgiou-Karistianis; Papp, Kate; Willia, Janet; Clark, Lee Anna; Downing, Nancy; Harreld, Michelle; Ready, Rebecca; Vaccarino, Anthony; Farias, Sarah; MacDonald, Marcy; Gusella, Jim; Myers, Rick; Ross, Christopher; Jones, Kathy; Marietta, Jacquie; Harris, Greg; Kim, Eun Young; Ennis, Greg; Ashburner, John; Potkin, Steve; Toga, Arthur; Axelson, Eric; Miller, Michael; Reading, Sarah; Beg, Mirza Faisal; Helmer, Karl; Lim, Kelvin; Lowe, Mark; Mori, Sasumu; Song, Allen; Turner, Jessica; Beall, Erik; Koenig, Katherine; Phillips, Michael; Zimbelman, Jan; Fiedorowicz, Jess; Robinson, Robert; Smith, Megan; Beglinger, Leigh; Williams, Janet; Liu, Dawei; Moser, David; Rowe, Kelly; Anderson, Karen; Groves, Mark; Rickards, Hugh; Van Duijn, Eric; Kim, Ji In; Zhang, Ying; Lu, Wenjing; Stout, Craig; Lourens, Spencer; Nance, Martha; Thompson, Sean; Erwin, Cheryl; Hughes, Lisa; Smith, Jim; Zschiegner, Roland; Wyse, Ryan; Wade, Owen; Weston, Derek; Werling-Witkoske, Chris; Anderson, Karla; Lichty, Brittany; Davis, Leann; Danzer, Phil.
In: Human Brain Mapping, Vol. 35, No. 3, 03.2014, p. 792-809.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis
AU - Younes, Laurent
AU - Ratnanather, J. Tilak
AU - Brown, Timothy
AU - Aylward, Elizabeth
AU - Nopoulos, Peg
AU - Johnson, Hans
AU - Magnotta, Vincent A.
AU - Paulsen, Jane S.
AU - Margolis, Russell L.
AU - Albin, Roger L.
AU - Miller, Michael I.
AU - Ross, Christopher A.
AU - Wassink, Thomas
AU - Cross, Stephen
AU - Kimble, Mycah
AU - Ryan, Patricia
AU - Epping, Eric A.
AU - Chiu, Edmond
AU - Yastrubetskaya, Olga
AU - Preston, Joy
AU - Goh, Anita
AU - Psych, D.
AU - Antonopoulos, Stephanie
AU - Loi, Samantha
AU - Chua, Phyllis
AU - Komiti, Angela
AU - Raymond, Lynn
AU - Decolongon, Joji
AU - Varvaris, Mark
AU - Mallonee, William M.
AU - Suter, Greg
AU - Samii, Ali
AU - Macaraeg, Alma
AU - Jones, Randi
AU - Wood-Siverio, Cathy
AU - Factor, Stewart A.
AU - Testa, Claudia
AU - Barker, Roger A.
AU - Mason, Sarah
AU - McCusker, Elizabeth
AU - Griffith, Jane
AU - Loy, Clement
AU - Gunn, David
AU - Orth, Michael
AU - Sübmuth, Sigurd
AU - Barth, Katrin
AU - Trautmann, Sonja
AU - Quaid, Kimberly
AU - Wesson, Melissa
AU - Wojcieszek, Joanne
AU - Guttman, Mark
AU - Sheinberg, Alanna
AU - Karmalkar, Irita
AU - Perlman, Susan
AU - Clemente, Brian
AU - Geschwind, Michael D.
AU - Kang, Gail
AU - Satris, Gabriela
AU - Warner, Tom
AU - Burrows, Maggie
AU - Rosser, Anne
AU - Price, Kathy
AU - Hunt, Sarah
AU - Marshall, Frederick
AU - Chesire, Amy
AU - Wodarski, Mary
AU - Hickey, Charlyne
AU - Panegyres, Peter
AU - Lee, Joseph
AU - Andrew, Steve
AU - Perlmutter, Joel
AU - Barton, Stacey
AU - Schmidt, Amy
AU - Miedzybrodzka, Zosia
AU - Rae, Daniela
AU - D'Alessandro, Mariella
AU - Craufurd, David
AU - Bek, Judith
AU - Howard, Elizabeth
AU - Mazzoni, Pietro
AU - Marder, Karen
AU - Wasserman, Paula
AU - Kumar, Rajeev
AU - Erickson, Diane
AU - Wheelock, Vicki
AU - Tempkin, Terry
AU - Kjer, Lisa
AU - Martin, Wayne
AU - King, Pamela
AU - Wieler, Marguerite
AU - Sran, Satwinder
AU - Suchowersky, Oksana
AU - Ahmed, Anwar
AU - Rao, Stephen
AU - Reece, Christine
AU - Bura, Alex
AU - Mourany, Lyla
AU - Schulz, Juliet
AU - Long, Jeffrey D.
AU - Montross, Kelsey
AU - Bockholt, Jeremy
AU - Blanchard, Steve
AU - Evans, Ken
AU - Matson, Wayne
AU - Peterson, Asa
AU - Mills, James A.
AU - Vonsattel, Jean Paul
AU - Moskowitz, Carol
AU - Vik, Stacie
AU - Harrington, Deborah
AU - Castillo, Gabriel
AU - Morison, Jessica
AU - Reed, Jason
AU - Diaz, Michael
AU - Dobbins, Ian
AU - Hershey, Tamara
AU - Foster, Erin
AU - Moore, Deborah
AU - Westervelt, Holly
AU - Davis, Jennifer
AU - Tremont, Geoff
AU - David, J.
AU - Gehl, Carissa
AU - Matheson, Kirsty
AU - Siedlecki, Karen
AU - Walsem, Marleen Van
AU - Elias, Greg
AU - Gover, Mary
AU - Bernier, Rachel
AU - Carlozzi, Noelle
AU - Duff, Kevin
AU - Nellie Georgiou-Karistianis, Georgiou-Karistianis
AU - Papp, Kate
AU - Willia, Janet
AU - Clark, Lee Anna
AU - Downing, Nancy
AU - Harreld, Michelle
AU - Ready, Rebecca
AU - Vaccarino, Anthony
AU - Farias, Sarah
AU - MacDonald, Marcy
AU - Gusella, Jim
AU - Myers, Rick
AU - Ross, Christopher
AU - Jones, Kathy
AU - Marietta, Jacquie
AU - Harris, Greg
AU - Kim, Eun Young
AU - Ennis, Greg
AU - Ashburner, John
AU - Potkin, Steve
AU - Toga, Arthur
AU - Axelson, Eric
AU - Miller, Michael
AU - Reading, Sarah
AU - Beg, Mirza Faisal
AU - Helmer, Karl
AU - Lim, Kelvin
AU - Lowe, Mark
AU - Mori, Sasumu
AU - Song, Allen
AU - Turner, Jessica
AU - Beall, Erik
AU - Koenig, Katherine
AU - Phillips, Michael
AU - Zimbelman, Jan
AU - Fiedorowicz, Jess
AU - Robinson, Robert
AU - Smith, Megan
AU - Beglinger, Leigh
AU - Williams, Janet
AU - Liu, Dawei
AU - Moser, David
AU - Rowe, Kelly
AU - Anderson, Karen
AU - Groves, Mark
AU - Rickards, Hugh
AU - Van Duijn, Eric
AU - Kim, Ji In
AU - Zhang, Ying
AU - Lu, Wenjing
AU - Stout, Craig
AU - Lourens, Spencer
AU - Nance, Martha
AU - Thompson, Sean
AU - Erwin, Cheryl
AU - Hughes, Lisa
AU - Smith, Jim
AU - Zschiegner, Roland
AU - Wyse, Ryan
AU - Wade, Owen
AU - Weston, Derek
AU - Werling-Witkoske, Chris
AU - Anderson, Karla
AU - Lichty, Brittany
AU - Davis, Leann
AU - Danzer, Phil
PY - 2014/3
Y1 - 2014/3
N2 - Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.
AB - Huntington disease (HD) is a neurodegenerative disorder that involves preferential atrophy in the striatal complex and related subcortical nuclei. In this article, which is based on a dataset extracted from the PREDICT-HD study, we use statistical shape analysis with deformation markers obtained through "Large Deformation Diffeomorphic Metric Mapping" of cortical surfaces to highlight specific atrophy patterns in the caudate, putamen, and globus pallidus, at different prodromal stages of the disease. On the basis of the relation to cortico-basal ganglia circuitry, we propose that statistical shape analysis, along with other structural and functional imaging studies, may help expand our understanding of the brain circuitry affected and other aspects of the neurobiology of HD, and also guide the most effective strategies for intervention.
KW - Diffeomorphic mapping
KW - Pallidus atrophy
KW - Striatal atrophy
KW - Surface registration
KW - Surface-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=84893816723&partnerID=8YFLogxK
U2 - 10.1002/hbm.22214
DO - 10.1002/hbm.22214
M3 - Article
C2 - 23281100
AN - SCOPUS:84893816723
VL - 35
SP - 792
EP - 809
JO - Human Brain Mapping
JF - Human Brain Mapping
SN - 1065-9471
IS - 3
ER -