TY - JOUR
T1 - Region-Specific Summation Patterns Inform the Role of Cortical Areas in Selecting Motor Plans
AU - Chang, Steve W.C.
AU - Calton, Jeffrey L.
AU - Lawrence, Bonnie M.
AU - Dickinson, Anthony R.
AU - Snyder, Lawrence H.
N1 - Funding Information:
The work presented here was supported by the National Eye Institute (R01-EY012135 to L.H.S.) and the National Institute of Mental Health (R00-MH099093 to S.W.C.C.).
Publisher Copyright:
© The Author 2015. Published by Oxford University Press. All rights reserved.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Given an instruction regarding which effector to move and what location to move to, simply adding the effector and spatial signals together will not lead to movement selection. For this, a nonlinearity is required. Thresholds, for example, can be used to select a particular response and reject others. Here we consider another useful nonlinearity, a supralinear multiplicative interaction. To help select a motor plan, spatial and effector signals could multiply and thereby amplify each other. Such an amplification could constitute one step within a distributed network involved in response selection, effectively boosting one response while suppressing others. We therefore asked whether effector and spatial signals sum supralinearly for planning eye versus arm movements from the parietal reach region (PRR), the lateral intraparietal area (LIP), the frontal eye field (FEF), and a portion of area 5 (A5) lying just anterior to PRR. Unlike LIP neurons, PRR, FEF, and, to a lesser extent, A5 neurons show a supralinear interaction. Our results suggest that selecting visually guided eye versus arm movements is likely to be mediated by PRR and FEF but not LIP.
AB - Given an instruction regarding which effector to move and what location to move to, simply adding the effector and spatial signals together will not lead to movement selection. For this, a nonlinearity is required. Thresholds, for example, can be used to select a particular response and reject others. Here we consider another useful nonlinearity, a supralinear multiplicative interaction. To help select a motor plan, spatial and effector signals could multiply and thereby amplify each other. Such an amplification could constitute one step within a distributed network involved in response selection, effectively boosting one response while suppressing others. We therefore asked whether effector and spatial signals sum supralinearly for planning eye versus arm movements from the parietal reach region (PRR), the lateral intraparietal area (LIP), the frontal eye field (FEF), and a portion of area 5 (A5) lying just anterior to PRR. Unlike LIP neurons, PRR, FEF, and, to a lesser extent, A5 neurons show a supralinear interaction. Our results suggest that selecting visually guided eye versus arm movements is likely to be mediated by PRR and FEF but not LIP.
KW - frontal eye field
KW - lateral intraparietal area
KW - motor decision
KW - motor planning
KW - parietal reach region
UR - http://www.scopus.com/inward/record.url?scp=84965143138&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhv047
DO - 10.1093/cercor/bhv047
M3 - Article
C2 - 25778345
AN - SCOPUS:84965143138
SN - 1047-3211
VL - 26
SP - 2154
EP - 2166
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 5
ER -