Region-Specific Summation Patterns Inform the Role of Cortical Areas in Selecting Motor Plans

Steve W.C. Chang, Jeffrey L. Calton, Bonnie M. Lawrence, Anthony R. Dickinson, Lawrence H. Snyder

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Given an instruction regarding which effector to move and what location to move to, simply adding the effector and spatial signals together will not lead to movement selection. For this, a nonlinearity is required. Thresholds, for example, can be used to select a particular response and reject others. Here we consider another useful nonlinearity, a supralinear multiplicative interaction. To help select a motor plan, spatial and effector signals could multiply and thereby amplify each other. Such an amplification could constitute one step within a distributed network involved in response selection, effectively boosting one response while suppressing others. We therefore asked whether effector and spatial signals sum supralinearly for planning eye versus arm movements from the parietal reach region (PRR), the lateral intraparietal area (LIP), the frontal eye field (FEF), and a portion of area 5 (A5) lying just anterior to PRR. Unlike LIP neurons, PRR, FEF, and, to a lesser extent, A5 neurons show a supralinear interaction. Our results suggest that selecting visually guided eye versus arm movements is likely to be mediated by PRR and FEF but not LIP.

Original languageEnglish
Pages (from-to)2154-2166
Number of pages13
JournalCerebral Cortex
Volume26
Issue number5
DOIs
StatePublished - May 1 2016

Keywords

  • frontal eye field
  • lateral intraparietal area
  • motor decision
  • motor planning
  • parietal reach region

Fingerprint Dive into the research topics of 'Region-Specific Summation Patterns Inform the Role of Cortical Areas in Selecting Motor Plans'. Together they form a unique fingerprint.

Cite this