Regeneration through long nerve grafts in the swine model

Arthur Atchabahian, Eric M. Genden, Susan E. Mackinnon, Vaishali B. Doolabh, Daniel A. Hunter

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

We investigated regeneration across a long nerve defect in the swine model to study extensive neural loss and long nerve gap. Most experiments have been conducted in the rodent model that, while an appropriate immunological model, only allows shod nerve gaps to be studied. Twelve outbred swine received either an 8-cm ulnar nerve autograft or an allograft without immunosuppression. At 6 and 10 months, histomorphometry of the autografts demonstrated excellent nerve regeneration, while very poor regeneration was noted across the allografts. This confirmed that 8 cm are an adequate challenge independent of the spontaneous regeneration potential of axons seen in rodents. The swine ulnar nerve graft model causes minimal morbidity and will now be used with immunological manipulation of inbred animals.

Original languageEnglish
Pages (from-to)379-382
Number of pages4
JournalMicrosurgery
Volume18
Issue number6
DOIs
StatePublished - Dec 10 1998

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