TY - JOUR
T1 - Regeneration and bioengineering of transplantable abdominal organs
T2 - Current status and future challenges
AU - Ross, Christina L.
AU - Booth, Christopher
AU - Sanders, Brian
AU - Babbar, Paurush
AU - Bergman, Christopher
AU - Soker, Tom
AU - Sittadjody, Sivanandane
AU - Salvatori, Marcus
AU - Al-Shraideh, Yousef
AU - Stratta, Robert J.
AU - Orlando, Giuseppe
PY - 2013/1
Y1 - 2013/1
N2 - Introduction: The most critical issue to organ transplantation is the identification of new sources of organs. The present manuscript illustrates the state-of-the-art regenerative medicine (RM) investigations aiming to manufacturing abdominal organs for transplant purposes. Areas covered: This manuscript focuses on research in the bioengineering and regeneration of kidneys, insulin-producing cells, livers and small bowel. The main technology currently under development exploits the seeding of cells on supporting scaffolding material. Despite favorable preliminary results obtained with relatively simple, hollow organs, when more complex organs are considered, the scenario changes dramatically. Investigations are still in early stages, and clinical translation is not yet foreseeable based on current knowledge and information. Obstacles are numerous but we believe the critical factor hampering success is lack of in-depth understanding of the extracellular matrix (ECM) and cell-ECM interactions, as well as the mechanisms with which organs develop in utero. Expert opinion: The success of RM to generate transplantable abdominal organs relies heavily on progress in (stem) cell therapies, developmental and ECM biology, and in the thorough understanding of the intricate relationship and interplay between cells and the ECM. This will require enormous investments in financial and medical resources, which ideally should be embarked upon by governments, the private sector and academia.
AB - Introduction: The most critical issue to organ transplantation is the identification of new sources of organs. The present manuscript illustrates the state-of-the-art regenerative medicine (RM) investigations aiming to manufacturing abdominal organs for transplant purposes. Areas covered: This manuscript focuses on research in the bioengineering and regeneration of kidneys, insulin-producing cells, livers and small bowel. The main technology currently under development exploits the seeding of cells on supporting scaffolding material. Despite favorable preliminary results obtained with relatively simple, hollow organs, when more complex organs are considered, the scenario changes dramatically. Investigations are still in early stages, and clinical translation is not yet foreseeable based on current knowledge and information. Obstacles are numerous but we believe the critical factor hampering success is lack of in-depth understanding of the extracellular matrix (ECM) and cell-ECM interactions, as well as the mechanisms with which organs develop in utero. Expert opinion: The success of RM to generate transplantable abdominal organs relies heavily on progress in (stem) cell therapies, developmental and ECM biology, and in the thorough understanding of the intricate relationship and interplay between cells and the ECM. This will require enormous investments in financial and medical resources, which ideally should be embarked upon by governments, the private sector and academia.
KW - Immunocloacking
KW - Immunoisolation
KW - Islet encapsulation
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=84870902898&partnerID=8YFLogxK
U2 - 10.1517/14712598.2013.732063
DO - 10.1517/14712598.2013.732063
M3 - Review article
C2 - 23110384
AN - SCOPUS:84870902898
SN - 1471-2598
VL - 13
SP - 103
EP - 113
JO - Expert opinion on biological therapy
JF - Expert opinion on biological therapy
IS - 1
ER -