Reference typing report for complement receptor 1 (CR1)

J. M. Moulds, M. Brai, J. Cohen, A. Cortelazzo, M. Cuccia, M. Lin, S. Sadallah, J. Schifferli, V. Bala Subramanian, L. Truedsson, G. W. Wu, F. Zhang, J. P. Atkinson

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34 Scopus citations

Abstract

A total of 100 Chinese blood donors (50 from Shen-Zhen and 50 from Taiwan) were studied by the participants in addition to 9 reference samples. A new nomenclature for the CR1 structural alleles was recommended by the participants which would use a numbering system, e,g, CR1*1. The structural allele frequencies in the Chinese were: CR1*1 (190 kD) 0.96, CR1*2 (220 kD) 0.03, CR1*3 (160 kD) 0.01 and CR1*4 (250 kD) 0.00. The HindIII expression polymorphism was also studied and the high expressing allele had a gene frequency of 0.71 while the low expressor gene frequency was 0.28. Erythrocyte copy numbers were quantified and compared between laboratories with good correlation (R = 0.55-0.88). The mean (± SD) erythrocyte copy number was 463 (± 229) in the Taiwan donors and 446 (± 207) in the Mainland Chinese.

Original languageEnglish
Pages (from-to)291-294
Number of pages4
JournalExperimental and Clinical Immunogenetics
Volume15
Issue number4
DOIs
StatePublished - 1998

Keywords

  • CD35
  • CR1
  • Complement receptor
  • Polymorphism

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