Reference typing report for complement receptor 1 (CR1)

J. M. Moulds; M. Brai; J. Cohen; A. Cortelazzo; M. Cuccia; M. Lin; S. Sadallah; J. Schifferli; V. Bala Subramanian; L. Truedsson; G. W. Wu; F. Zhang; J. P. Atkinson

doi:10.1159/000019084

Reference typing report for complement receptor 1 (CR1)

J. M. Moulds, M. Brai, J. Cohen, A. Cortelazzo, M. Cuccia, M. Lin, S. Sadallah, J. Schifferli, V. Bala Subramanian, L. Truedsson, G. W. Wu, F. Zhang, J. P. Atkinson

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A total of 100 Chinese blood donors (50 from Shen-Zhen and 50 from Taiwan) were studied by the participants in addition to 9 reference samples. A new nomenclature for the CR1 structural alleles was recommended by the participants which would use a numbering system, e,g, CR1*1. The structural allele frequencies in the Chinese were: CR1*1 (190 kD) 0.96, CR1*2 (220 kD) 0.03, CR1*3 (160 kD) 0.01 and CR1*4 (250 kD) 0.00. The HindIII expression polymorphism was also studied and the high expressing allele had a gene frequency of 0.71 while the low expressor gene frequency was 0.28. Erythrocyte copy numbers were quantified and compared between laboratories with good correlation (R = 0.55-0.88). The mean (± SD) erythrocyte copy number was 463 (± 229) in the Taiwan donors and 446 (± 207) in the Mainland Chinese.

Original language	English
Pages (from-to)	291-294
Number of pages	4
Journal	Experimental and Clinical Immunogenetics
Volume	15
Issue number	4
DOIs	https://doi.org/10.1159/000019084
State	Published - 1998

Keywords

CD35
CR1
Complement receptor
Polymorphism

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10.1159/000019084

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title = "Reference typing report for complement receptor 1 (CR1)",

abstract = "A total of 100 Chinese blood donors (50 from Shen-Zhen and 50 from Taiwan) were studied by the participants in addition to 9 reference samples. A new nomenclature for the CR1 structural alleles was recommended by the participants which would use a numbering system, e,g, CR1*1. The structural allele frequencies in the Chinese were: CR1*1 (190 kD) 0.96, CR1*2 (220 kD) 0.03, CR1*3 (160 kD) 0.01 and CR1*4 (250 kD) 0.00. The HindIII expression polymorphism was also studied and the high expressing allele had a gene frequency of 0.71 while the low expressor gene frequency was 0.28. Erythrocyte copy numbers were quantified and compared between laboratories with good correlation (R = 0.55-0.88). The mean (± SD) erythrocyte copy number was 463 (± 229) in the Taiwan donors and 446 (± 207) in the Mainland Chinese.",

keywords = "CD35, CR1, Complement receptor, Polymorphism",

author = "Moulds, {J. M.} and M. Brai and J. Cohen and A. Cortelazzo and M. Cuccia and M. Lin and S. Sadallah and J. Schifferli and {Bala Subramanian}, V. and L. Truedsson and Wu, {G. W.} and F. Zhang and Atkinson, {J. P.}",

year = "1998",

doi = "10.1159/000019084",

language = "English",

volume = "15",

pages = "291--294",

journal = "Experimental and Clinical Immunogenetics",

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Reference typing report for complement receptor 1 (CR1). / Moulds, J. M.; Brai, M.; Cohen, J.; Cortelazzo, A.; Cuccia, M.; Lin, M.; Sadallah, S.; Schifferli, J.; Bala Subramanian, V.; Truedsson, L.; Wu, G. W.; Zhang, F.; Atkinson, J. P.

In: Experimental and Clinical Immunogenetics, Vol. 15, No. 4, 1998, p. 291-294.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Reference typing report for complement receptor 1 (CR1)

AU - Moulds, J. M.

AU - Brai, M.

AU - Cohen, J.

AU - Cortelazzo, A.

AU - Cuccia, M.

AU - Lin, M.

AU - Sadallah, S.

AU - Schifferli, J.

AU - Bala Subramanian, V.

AU - Truedsson, L.

AU - Wu, G. W.

AU - Zhang, F.

AU - Atkinson, J. P.

PY - 1998

Y1 - 1998

N2 - A total of 100 Chinese blood donors (50 from Shen-Zhen and 50 from Taiwan) were studied by the participants in addition to 9 reference samples. A new nomenclature for the CR1 structural alleles was recommended by the participants which would use a numbering system, e,g, CR1*1. The structural allele frequencies in the Chinese were: CR1*1 (190 kD) 0.96, CR1*2 (220 kD) 0.03, CR1*3 (160 kD) 0.01 and CR1*4 (250 kD) 0.00. The HindIII expression polymorphism was also studied and the high expressing allele had a gene frequency of 0.71 while the low expressor gene frequency was 0.28. Erythrocyte copy numbers were quantified and compared between laboratories with good correlation (R = 0.55-0.88). The mean (± SD) erythrocyte copy number was 463 (± 229) in the Taiwan donors and 446 (± 207) in the Mainland Chinese.

AB - A total of 100 Chinese blood donors (50 from Shen-Zhen and 50 from Taiwan) were studied by the participants in addition to 9 reference samples. A new nomenclature for the CR1 structural alleles was recommended by the participants which would use a numbering system, e,g, CR1*1. The structural allele frequencies in the Chinese were: CR1*1 (190 kD) 0.96, CR1*2 (220 kD) 0.03, CR1*3 (160 kD) 0.01 and CR1*4 (250 kD) 0.00. The HindIII expression polymorphism was also studied and the high expressing allele had a gene frequency of 0.71 while the low expressor gene frequency was 0.28. Erythrocyte copy numbers were quantified and compared between laboratories with good correlation (R = 0.55-0.88). The mean (± SD) erythrocyte copy number was 463 (± 229) in the Taiwan donors and 446 (± 207) in the Mainland Chinese.

KW - CD35

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KW - Polymorphism

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JO - Experimental and Clinical Immunogenetics

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Reference typing report for complement receptor 1 (CR1)

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