TY - JOUR
T1 - Reevaluation of the standardized uptake value for FDG
T2 - Variations with body weight and methods for correction
AU - Sugawara, Yoshifumi
AU - Zasadny, Kenneth R.
AU - Neuhoff, Alex W.
AU - Wahl, Richard L.
PY - 1999/11
Y1 - 1999/11
N2 - PURPOSE: To reevaluate the relationships between standardized uptake values (SUVS) and body weight by using positron emission tomography (PET) with 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG). MATERIALS AND METHODS: FDG PET scanning was performed in 138 female patients with known or suspected primary breast cancers. SUVs in blood and tumor (n = 79) were calculated by using body weight (SUV(bw)), ideal body weight (SUV(ibw)), lean body mass (SUV(ibw)), and body surface area (SUV(bsa)) on images obtained 50-60 minutes after the injection of FDG. RESULTS: There was a strong positive correlation between the blood SUV(bw) and body weight (r = 0.705, P < .001). The blood SUV(ibw) reduced the weight dependence but showed a negative correlation with body weight (r = -0.296, P < .001). Both the blood SUV(ibm) and SUV(bsa) eliminated the weight dependence and showed no correlation with body weight (r = -0.010, P = .904 and r = 0.106, P = .215, respectively). Although there was a wide variance in the tumor SUV(bw), it showed a weak but significant positive correlation with body weight (r = 0.207, P = 033). Plots of the tumor SUV(ibm) and SUV(bsa) versus body weight showed relatively flat slopes. CONCLUSION: SUV(ibm) and SUV(bsa) are weight-independent indices for FDG uptake, and SUV(ibm) appears to be more appropriate for quantifying FDG uptake to avoid overestimation of glucose utilization in obese patients.
AB - PURPOSE: To reevaluate the relationships between standardized uptake values (SUVS) and body weight by using positron emission tomography (PET) with 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG). MATERIALS AND METHODS: FDG PET scanning was performed in 138 female patients with known or suspected primary breast cancers. SUVs in blood and tumor (n = 79) were calculated by using body weight (SUV(bw)), ideal body weight (SUV(ibw)), lean body mass (SUV(ibw)), and body surface area (SUV(bsa)) on images obtained 50-60 minutes after the injection of FDG. RESULTS: There was a strong positive correlation between the blood SUV(bw) and body weight (r = 0.705, P < .001). The blood SUV(ibw) reduced the weight dependence but showed a negative correlation with body weight (r = -0.296, P < .001). Both the blood SUV(ibm) and SUV(bsa) eliminated the weight dependence and showed no correlation with body weight (r = -0.010, P = .904 and r = 0.106, P = .215, respectively). Although there was a wide variance in the tumor SUV(bw), it showed a weak but significant positive correlation with body weight (r = 0.207, P = 033). Plots of the tumor SUV(ibm) and SUV(bsa) versus body weight showed relatively flat slopes. CONCLUSION: SUV(ibm) and SUV(bsa) are weight-independent indices for FDG uptake, and SUV(ibm) appears to be more appropriate for quantifying FDG uptake to avoid overestimation of glucose utilization in obese patients.
KW - Breast neoplasms, PET
KW - Breast neoplasms, radionuclide studies
KW - Fluorine, radioactive
KW - Glucose
KW - Positron emission tomography (PET)
UR - http://www.scopus.com/inward/record.url?scp=0032712660&partnerID=8YFLogxK
U2 - 10.1148/radiology.213.2.r99nv37521
DO - 10.1148/radiology.213.2.r99nv37521
M3 - Article
C2 - 10551235
AN - SCOPUS:0032712660
SN - 0033-8419
VL - 213
SP - 521
EP - 525
JO - Radiology
JF - Radiology
IS - 2
ER -