TY - JOUR
T1 - Redundant control of adipogenesis by histone deacetylases 1 and 2
AU - Haberland, Michael
AU - Carrer, Michele
AU - Mokalled, Mayssa H.
AU - Montgomery, Rusty L.
AU - Olson, Eric N.
PY - 2010/5/7
Y1 - 2010/5/7
N2 - Adipocyte differentiation is a well defined process that is under the control of transcriptional activators and repressors. Weshow that histone deacetylase (HDAC) inhibitors efficiently block adipocyte differentiation in vitro. This effect is specific to adipogenesis, as another mesenchymal differentiation process, osteoblastogenesis, is enhanced upon HDAC inhibition. Through the systematic genetic deletion of HDAC genes in cultured mesenchymal precursor cells, we show that deletion of HDAC1 and HDAC2 leads to reduced lipid accumulation, revealing redundant and requisite roles of these class I HDACs in adipogenesis. These findings unveil a previously unrecognized role for HDACs in the control of adipogenesis.
AB - Adipocyte differentiation is a well defined process that is under the control of transcriptional activators and repressors. Weshow that histone deacetylase (HDAC) inhibitors efficiently block adipocyte differentiation in vitro. This effect is specific to adipogenesis, as another mesenchymal differentiation process, osteoblastogenesis, is enhanced upon HDAC inhibition. Through the systematic genetic deletion of HDAC genes in cultured mesenchymal precursor cells, we show that deletion of HDAC1 and HDAC2 leads to reduced lipid accumulation, revealing redundant and requisite roles of these class I HDACs in adipogenesis. These findings unveil a previously unrecognized role for HDACs in the control of adipogenesis.
UR - http://www.scopus.com/inward/record.url?scp=77952002655&partnerID=8YFLogxK
U2 - 10.1074/jbc.M109.081679
DO - 10.1074/jbc.M109.081679
M3 - Article
C2 - 20190228
AN - SCOPUS:77952002655
SN - 0021-9258
VL - 285
SP - 14663
EP - 14670
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 19
ER -