Reduction of subacute stent thrombosis (SAT) using heparin-coated stents in a large-scale, "real world" registry

Vishal Gupta, Bhooma R. Aravamuthan, Susan Baskerville, Susan K. Smith, Vijaya Gupta, Michael A. Lauer, Tim A. Fischell

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34 Scopus citations


Purpose. This study was designed to compare the rates of subacute stent thrombosis (SAT) among patients receiving heparin-coated stents to patients receiving bare-metal stents in real world, contemporary coronary interventions. Background. Controlled trials with heparin-coated coronary stents have shown a trend toward decreased rates of SAT. Methods and Results. The data in this study were collected from a single, large cardiac center over a period of 9 months. All patients who underwent coronary stent implantation during this 9-month period were included in the study (1,288 patients; 1,366 procedures; 2,231 stents). All patients were treated with aspirin and clopidogrel (or tidopidine) after stenting. Primary thrombotic outcome was defined as angiographically documented SAT and/or sudden unexplained cardiac death (SCD) within 30 days of the procedure. Follow-up data (1,264/1,276 patients) were obtained in 99% of patients. A total of 337 patients received 543 heparin-coated stents (BX Velocity™ Hepacoat™) and 939 patients received bare-metal stents (1,688 stents). SAT was seen in 25/1,024 procedures (2.44%) in the bare-metal stent group and 1/342 procedures (0.29%) in the heparin-coated stent group. Primary thrombotic outcomes (SAT or SCD) were observed in 31/1,024 procedures (3.03%) in the bare-metal stent cohort and in 2/342 procedures (0.58%) in the heparin-coated stent group. The vast majority (96%) of the patients who had SAT within 30 days had initial stent placement for an acute coronary syndrome (p < 0.0001). Conclusion. This large, single-center registry demonstrates a significant reduction of SAT using heparin-coated stents compared to bare-metal stents in real world coronary interventions.

Original languageEnglish
Pages (from-to)304-310
Number of pages7
JournalJournal of Invasive Cardiology
Issue number6
StatePublished - Jun 1 2004


  • Angioplasty
  • Biocompatible
  • Blood vessel prosthesis implantation
  • Coated materials
  • Complications
  • Percutaneous transluminal coronary intervention


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