A method for reducing physical assignments of markers to a lod score table is described, and these tables are added to those from family data to provide a consistent genetic map of chromosome 1. Various chiasma maps are considered, and the results suggest that terminalization of chiasmata does occur. Chiasmata appear to be significantly less localized in oocytes than spermatocytes, and crossing-over in the vicinity of the centromere is more common in females than in males.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalHuman genetics
Issue number3
StatePublished - Feb 1981


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