Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial

Paulette D. Chandler; Foluso Agboola; Kimmie Ng; Jamil B. Scott; Bettina F. Drake; Gary G. Bennett; Andrew T. Chan; Bruce W. Hollis; Karen M. Emmons; Charles S. Fuchs; Edward L. Giovannucci

doi:10.1186/s40795-015-0024-8

Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial

Paulette D. Chandler
, Foluso Agboola
, Kimmie Ng
, Jamil B. Scott
, Bettina F. Drake
, Gary G. Bennett
, Andrew T. Chan
, Bruce W. Hollis
, Karen M. Emmons
, Charles S. Fuchs
, Edward L. Giovannucci

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:

Original language	English
Article number	26
Journal	BMC Nutrition
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/s40795-015-0024-8
State	Published - Jul 30 2015

Keywords

Blacks
Parathyroid hormone
Supplementation
Vitamin D

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10.1186/s40795-015-0024-8

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@article{31b2096d43964531983860df489c2350,

title = "Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial",

abstract = "Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:",

keywords = "Blacks, Parathyroid hormone, Supplementation, Vitamin D",

author = "Chandler, \{Paulette D.\} and Foluso Agboola and Kimmie Ng and Scott, \{Jamil B.\} and Drake, \{Bettina F.\} and Bennett, \{Gary G.\} and Chan, \{Andrew T.\} and Hollis, \{Bruce W.\} and Emmons, \{Karen M.\} and Fuchs, \{Charles S.\} and Giovannucci, \{Edward L.\}",

note = "Publisher Copyright: {\textcopyright} 2015 Chandler et al.",

year = "2015",

month = jul,

day = "30",

doi = "10.1186/s40795-015-0024-8",

language = "English",

volume = "1",

journal = "BMC Nutrition",

issn = "2055-0928",

number = "1",

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T1 - Reduction of parathyroid hormone with vitamin D supplementation in blacks

T2 - A randomized controlled trial

AU - Chandler, Paulette D.

AU - Agboola, Foluso

AU - Ng, Kimmie

AU - Scott, Jamil B.

AU - Drake, Bettina F.

AU - Bennett, Gary G.

AU - Chan, Andrew T.

AU - Hollis, Bruce W.

AU - Emmons, Karen M.

AU - Fuchs, Charles S.

AU - Giovannucci, Edward L.

PY - 2015/7/30

Y1 - 2015/7/30

N2 - Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:

AB - Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov:

KW - Blacks

KW - Parathyroid hormone

KW - Supplementation

KW - Vitamin D

UR - https://www.scopus.com/pages/publications/85079465837

U2 - 10.1186/s40795-015-0024-8

DO - 10.1186/s40795-015-0024-8

M3 - Article

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SN - 2055-0928

VL - 1

JO - BMC Nutrition

JF - BMC Nutrition

IS - 1

M1 - 26

ER -

Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial

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