Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial

Paulette D. Chandler, Foluso Agboola, Kimmie Ng, Jamil B. Scott, Bettina F. Drake, Gary G. Bennett, Andrew T. Chan, Bruce W. Hollis, Karen M. Emmons, Charles S. Fuchs, Edward L. Giovannucci

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2 Scopus citations

Abstract

Background: Response of parathyroid hormone (PTH) to vitamin D supplementation is determined by the baseline PTH level and change in vitamin D status. Conflicting reports in Blacks exist on the PTH response to vitamin D to supplementation. Methods: During 3 winters from 2007 to 2010, 328 healthy Blacks (median age, 51 years) living in Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. PTH was measured in 254 participants at baseline and at the end of vitamin D supplementation period. Results: The differences in PTH between baseline and 3 months were 3.93 pg/mL for those receiving placebo, -3.37 pg/mL for those receiving 1000 IU/d, -6.76 pg/mL for those receiving 2000 IU/d, and -8.99 pg/mL for those receiving 4000 IU/d (-2.98 pg/mL for each additional 1000 IU/d of vitamin D3; p < 0.001). Conclusion: We found a significant decrease in PTH with increasing doses of vitamin D supplementation up to intakes of 4000 IU/d in Blacks. Trial registration: Clinical Trials.gov: NCT00585637

Original languageEnglish
Article number26
JournalBMC Nutrition
Volume1
Issue number1
DOIs
StatePublished - Jul 30 2015

Keywords

  • Blacks
  • Parathyroid hormone
  • Supplementation
  • Vitamin D

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    Chandler, P. D., Agboola, F., Ng, K., Scott, J. B., Drake, B. F., Bennett, G. G., Chan, A. T., Hollis, B. W., Emmons, K. M., Fuchs, C. S., & Giovannucci, E. L. (2015). Reduction of parathyroid hormone with vitamin D supplementation in blacks: A randomized controlled trial. BMC Nutrition, 1(1), [26]. https://doi.org/10.1186/s40795-015-0024-8