Reducing Treatment Burden in AMD

Rajendra S. Apte

doi:10.1016/j.cell.2020.02.028

Reducing Treatment Burden in AMD

Rajendra S. Apte

Research output: Contribution to journal › Comment/debate

8 Scopus citations

Abstract

VEGF-A antagonists have revolutionized wet AMD treatment. Several challenges remain including high treatment burden requiring repeated intraocular injections for persistent disease. Brolucizumab directly inhibits VEGF-A function, providing visual outcomes comparable to aflibercept (an FDA-approved VEGF-A antagonist). Anatomic retinal outcomes including retinal fluid, a marker of disease activity, favored brolucizumab. To view this Bench to Bedisde, open or download the PDF.

Original language	English
Pages (from-to)	1033
Number of pages	1
Journal	Cell
Volume	180
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2020.02.028
State	Published - Mar 19 2020

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10.1016/j.cell.2020.02.028

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title = "Reducing Treatment Burden in AMD",

abstract = "VEGF-A antagonists have revolutionized wet AMD treatment. Several challenges remain including high treatment burden requiring repeated intraocular injections for persistent disease. Brolucizumab directly inhibits VEGF-A function, providing visual outcomes comparable to aflibercept (an FDA-approved VEGF-A antagonist). Anatomic retinal outcomes including retinal fluid, a marker of disease activity, favored brolucizumab. To view this Bench to Bedisde, open or download the PDF.",

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N2 - VEGF-A antagonists have revolutionized wet AMD treatment. Several challenges remain including high treatment burden requiring repeated intraocular injections for persistent disease. Brolucizumab directly inhibits VEGF-A function, providing visual outcomes comparable to aflibercept (an FDA-approved VEGF-A antagonist). Anatomic retinal outcomes including retinal fluid, a marker of disease activity, favored brolucizumab. To view this Bench to Bedisde, open or download the PDF.

AB - VEGF-A antagonists have revolutionized wet AMD treatment. Several challenges remain including high treatment burden requiring repeated intraocular injections for persistent disease. Brolucizumab directly inhibits VEGF-A function, providing visual outcomes comparable to aflibercept (an FDA-approved VEGF-A antagonist). Anatomic retinal outcomes including retinal fluid, a marker of disease activity, favored brolucizumab. To view this Bench to Bedisde, open or download the PDF.

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U2 - 10.1016/j.cell.2020.02.028

DO - 10.1016/j.cell.2020.02.028

M3 - Comment/debate

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AN - SCOPUS:85081669038

SN - 0092-8674

VL - 180

SP - 1033

JO - Cell

JF - Cell

IS - 6

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Reducing Treatment Burden in AMD

Abstract

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