Reduced type I collagen utilization: A pathogenic mechanism in COL5A1 haplo-insufficient Ehlers-Danlos syndrome

Keyphrases

• Type I Collagen 100%
• Pathogenic Mechanism 100%
• Ehlers-Danlos Syndrome 100%
• COL5A1 100%
• Reduced Type 100%
• Type V Collagen 100%
• Collagen 80%
• Haploinsufficiency 40%
• Collagen Synthesis 40%
• Total Collagen 40%
• Collagen Fibrils 40%
• Osteogenesis Imperfecta 40%
• Dermal Fibroblasts 20%
• Connective Tissue 20%
• Fibroblasts 20%
• Highly Sensitive 20%
• Cell Culture 20%
• Collagen Ratio 20%
• Small Fraction 20%
• Synthesis Rate 20%
• Hydroxyproline 20%
• Fibril Morphology 20%
• V-type 20%
• Matrix Deposition 20%
• Reduced Rate 20%
• Out of Proportion 20%
• Fibroblast Culture 20%
• Collagen Fibril Diameter 20%

Biochemistry, Genetics and Molecular Biology

• Type I Collagen 100%
• Type-V Collagen 100%
• Bone Development 40%
• Haploinsufficiency 40%
• Collagen Synthesis 40%
• Cell Culture 20%
• Fibroblast Culture 20%
• Fibroblast 20%