TY - JOUR
T1 - Reduced field-of-view diffusion-weighted imaging of the brain at 7 T
AU - von Morze, Cornelius
AU - Kelley, Douglas A.C.
AU - Shepherd, Timothy M.
AU - Banerjee, Suchandrima
AU - Xu, Duan
AU - Hess, Christopher P.
N1 - Funding Information:
We acknowledge grant support from NIH R01EB009756. TMS was supported by the NIH/NIBIB T32 EB001631 training fellowship.
PY - 2010/12
Y1 - 2010/12
N2 - Ventral and rostral regions of the brain are of emerging importance for the MRI characterization of early dementia, traumatic brain injury and epilepsy. Unfortunately, standard single-shot echo planar diffusion-weighted imaging of these regions at high fields is contaminated by severe imaging artifacts in the vicinity of air-tissue interfaces. To mitigate these artifacts and improve visualization of the temporal and frontal lobes at 7 T, we applied a reduced field-of-view strategy, enabled by outer volume suppression (OVS) with novel quadratic phase radiofrequency (RF) pulses, combined with partial Fourier and parallel imaging methods. The new acquisition greatly reduced the level of artifacts in six human subjects (including four patients with early symptoms of dementia).
AB - Ventral and rostral regions of the brain are of emerging importance for the MRI characterization of early dementia, traumatic brain injury and epilepsy. Unfortunately, standard single-shot echo planar diffusion-weighted imaging of these regions at high fields is contaminated by severe imaging artifacts in the vicinity of air-tissue interfaces. To mitigate these artifacts and improve visualization of the temporal and frontal lobes at 7 T, we applied a reduced field-of-view strategy, enabled by outer volume suppression (OVS) with novel quadratic phase radiofrequency (RF) pulses, combined with partial Fourier and parallel imaging methods. The new acquisition greatly reduced the level of artifacts in six human subjects (including four patients with early symptoms of dementia).
KW - Brain
KW - Diffusion-weighted imaging
KW - Field of view
UR - http://www.scopus.com/inward/record.url?scp=78449265028&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2010.06.025
DO - 10.1016/j.mri.2010.06.025
M3 - Article
C2 - 20850242
AN - SCOPUS:78449265028
SN - 0730-725X
VL - 28
SP - 1541
EP - 1545
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
IS - 10
ER -